首頁師資〉教師指導學生

張南山

張南山 (Chang, Nan-Shan, Ph.D.)

分子醫學研究所  特聘教授 分機:5268  E-mail : changns@mail.ncku.edu.tw

Research interests

  1. Mechanism of apoptosis: Role of WW domain-containing oxidoreductase WOX1 in regulation of mitochondrial apoptosis and cancerous progression.  We discovered this gene in year 2000, and have been the leader in the field (research supported by NSC, NHRI, & Dept. Defense USA).
  2. Signaling transduction and neurodegeneration: Elucidating signaling network that controls neurodegeneration (research supported by NSC & NHRI).
  3. Naturally occurring small-size anticancer proteins: Role of Zfra in protein turnover and tumor progression (research supported by Dept. Defense USA& DOH, Taiwan).

Recent Publications

  1. Huang SS, SuWP, Lin HP, Chang NS (2016) Role of WW domain-containing oxidoreductase WWOX in driving maturation of T-cell acute lymphoblastic leukemia maturation. J Biol Chem 291, 17319-17331. 

  2. Su WP, Wang WJ, Sze CI, Chang NS (2016) Zfra induction of memory anticancer response via a novel immune cell. Oncoimmunology 5, e1213935.
  3. Hsu LJ, Chiang MF, Sze CI, Su WP, Yap YV, Lee IT, Kuo HL, Chang NS (2016) Membrane hyaluronidase HYAL-2 in WWOX and SMAD signaling. Front Cell Dev Biol 4, 141.
  4. Lee MH, Shih YH, Lin SR, Chang JY, Lin YH, Sze CI, Kuo YM, Chang NS (2017) Zfra restores memory deficits in Alzheimer’s disease triple transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau and amyloid β and inflammatory NF-κB activation. Alzheimers Dement (N Y)3, 189-204.
  5. Hsu LJ, Hong Q, Chen ST, Kuo HL, Schultz L, Heath J, Lin SR, Lee MH, Li DZ, Li ZL, Cheng HC, Armand G, Chang NS (2017) Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget8, 9137-19155.
  6. Kuo HL, Ho PC, Huang SS, Chang NS (2018) Chasing the signaling run by tri-molecular time-lapse FRET microscopy.Cell Death Discovery4, 45.
  7. Huang SS, Chang NS. (2018) Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events. Exp Biol Med 243, 137-147
  8. Liu CC, Ho PC, Lee IT, Chen YA, Chu CH, Teng CC, Wu SN, Sze CI, Chiang MF, Chang NS (2018) WWOX Phosphorylation, Signaling, and Role in Neurodegeneration.Front Neurosci 12, 563.
  9. Chen YA, Lu CY, Cheng TY, Pan SH, Chen HF and Chang NS (2019) WW Domain-Containing Proteins YAP and TAZ in the Hippo Pathway as Key Regulators in Stemness Maintenance, Tissue Homeostasis, and Tumorigenesis. Front. Oncol 9, 60. 
  10. Chang NS, Lin R, Sze CI, Aqeilan RI (2019) Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders. Front. Oncol9, 719.
  11. Chou PY, Lai FJ, Chen YA, Sie YD, Kuo HL, Su WP, Wu CY, Liu TY, Wen KY, Hsu LJ, Sze CI, Chang NS (2019) Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment. Cell Death Discov 5, 97.
  12. Chou PY, Lin SR, Lee MH, Schultz L, Sze CI, Chang NS (2019) A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism. Cell Commun Signal 17, 76.
  13. Wang WJ, Ho PC, Nagarajan G, Chen YA, Kuo HL, Subhan D, Su WP, Chang JY, Lu CY, Chang KT, Lin SR, Lee MH, Chang NS (2019) Identification of WWOX 7-21 and 7-11 peptides for activating spleen Hyal-2+ CD3- CD19- Z cells to kill melanoma and breast cancer cells in vivo. Cancers 11, 1818.
  14. Cheng YY, Chou YT, Lai FJ, Jan MS, Chang TH, Jou IM, Chen PS, Lo JY, Huang SS, Chang NS, Liou YT, Hsu PC, Cheng HC, Lin YS, Hsu LJ (2020)Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice.Acta Neuropathol Commun 8, 6.
  15. Huang SS, Hsu LJ, Chang NS (2020) Functional role of WW domain-containing proteins in tumor biology and diseases: insight into the role in ubiquitin-proteasome system. FASEB BioAdvances2, 234-253.
  16. Sze CI, Chang NS (2020) Functional antagonism between p53 and WWOX in leading to neurodegeneration in vivo. Proceedings of the Singapore National Academy of Science(invited submission).
  17. Chen YA, Chou PY, Sie YD, Chen ST, Chang NS (2020) Cell surface epitope WWOX286-299 in normal cells is responsible for repelling invading WWOX-negative cancer cells.  Communications Biology Nature, in review.