首頁師資〉專/兼任師資專長

張南山

張南山(Chang, Nan-Shan, Ph.D.)

分子醫學研究所 特聘教授/所長 分機:5268  E-mail : changns@mail.ncku.edu.tw

個人網頁:http://imm.med.ncku.edu.tw/c_website/faculty/Faculty_chinese/ns_c.htm

Research interests

  1. Mechanism of apoptosis:  Role of WW domain-containing oxidoreductase WOX1 in regulation of mitochondrial apoptosis and cancerous progression.  We discovered this gene in year 2000, and have been the leader in the field (research supported by NSC, NHRI, & Dept. Defense USA).
  2. Signaling transduction and neurodegeneration: Elucidating signaling network that controls neurodegeneration (research supported by NSC & NHRI).
  3. Naturally occurring small-size anticancer proteins: Role of Zfra in protein turnover and tumor progression (research supported by Dept. Defense USA& DOH, Taiwan).

Recent Publications

  1. Chang JY, LeeMH, LinSR, YangLY, SunHS, Sze CI, HongQ, LinYS, ChouYT, HsuLJ, Jan MS, Gong CX, Chang NS (2015) Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget (Focus on Aging)6, 3578-3589.
  2. Lin JT, Li HY, Chang NS, Lin CH, Chen YC, Lu PJ. (2015) WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase.Cell Cycle 14, 408-416.
  3. Lee MH, Su WP, Wang WJ, Lin SR, Lu CY, Chen YA, Chang JY, Huang SS, Chou PY, Ye SR, Chen SJ, He H, Liu TH, Chou YT, Hsu LJ, Lai FJ, Chen SJ, Lee HC, Kakhniashvili D, Goodman S, Chang NS (2015) Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo.Oncotarget6, 3737-3751.
  4. ChenSJ, LinPW, LinHP, HuangSS, Lai FJ, SheuHM, HsuLJ, Chang NS (2015) UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget 6, 8007-8018.
  5. Chang Y, Lan YY, Hsiao JR, Chang NS (2015) Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase.Exp Biol Med (Maywood). 240, 329-337.
  6. Sie YD, Li YC, Chang NS, Campagnola PJ, Chen SJ (2015) Fabrication of three-dimensional multi-protein microstructures for cell migration and adhesion enhancement. Biomedical Optics Express. 6, 480-490.
  7. Chang NS (2015) Introduction to a thematic issue for WWOX.Exp Biol Med (Maywood). 240, 281-284.
  8. Chang NS (2015) In Memoriam: Shur-Tzu (Su) Chen, a pioneer in tumor suppressor WWOX for neuroscience. J. Biomed. Sci. 22, 39.
  9. Chang JY, Chang NS (2015) WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau, amyloid b and apoptosis. Cell Death Discovery 1, 15003.
  10. Sze CI, KuoYM, HsuLJ, FuTF, Ming-Fu ChiangMF, Chang NS (2015) A cascade of protein aggregation in the mitochondria for causing neurodegeneration and apoptosis under WWOX deficiency (Invited News and Commentary). Cell Death Dis.6, e1881.*
  11. Chang NS (2016) Bubbling cell death: a hot air balloon released from the nucleus in the cold.Exp Biol Med (Maywood). 241, 1306-1315.*
  12. Huang SS, SuWP, Lin HP, Chang NS (2016) Role of WW domain-containing oxidoreductase WWOX in driving maturation of T-cell acute lymphoblastic leukemia maturation. J Biol Chem. 291, 17319-17331.
  13. Su WP, Wang WJ, Sze CI, Chang NS (2016) Zfra induction of memory anticancer response via a novel immune cell. Oncoimmunology5, e1213935.
  14. Hsu LJ, Hong Q, Chen ST, Kuo HL, Schultz L, Heath J, Lin SR, Lee MH, Li DZ, Li ZL, Cheng HC, Armand G, Chang NS (2016) Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget, in press.
  15. Hsu LJ, Chiang MF, Sze CI, Su WP, Yap YV, Lee IT, Kuo HL, Chang NS (2016) Membrane hyaluronidase HYAL-2 in WWOX and SMAD signaling. Front Cell Dev Biol. 4, 141.
  16. Chang NS (2016) WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway. J Tumor Res. 2, e101. (Editorial)
  17. Lee MH, Shih YH, Lin SR, Chang JY, Lin YH, Sze CI, Kuo YM, Chang NS (2017) Zfra restores memory deficits in Alzheimer’s disease triple transgenic mice by blocking aggregation of TRAPPC6AD, SH3GLB2, tau and amyloid b and inflammatory NF-kB activation. Alzheimer's & Dementia: Translational Research & Clinical Interventions, in press.