首頁師資〉專/兼任師資專長

張權發

張權發(Chang, Chuan-Fa, Ph.D.)

醫技所 副教授   

分機:5796    E-mail: affa@mail.ncku.edu.tw

個人網址: http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

研究興趣

  1. 利用醣質體蛋白體學方法研究腸病毒71型之致病機轉。
  2. 以醣質體及蛋白質體方法尋找癌細胞上新型醣類癌症標記。
  3. 研究醣類轉移酵素在細菌感染及入侵、以及癌細胞生長及轉移所扮演的角色。
  4. 醣類微矩陣晶片(Carbohydrate Microarray)製作及研究應用。

近五年代表作

  1. Functional characterization of a complex mutation in the α(1,4) galactosyltransferase gene in Taiwan individuals with p phenotype. Wang, Y. C., Chang, C. F., Lin, H. C., Lin, K. S., Lin, K. T., Hung, C. M., Lin, T. M. Transfusion Med., 2011, 21, 84-89.
  2. Profiling of influenza viruses by high-throughput carbohydrate membrane array. Lao, W. I., Wang, Y. F., Kuo, Y. D., Lin, C. H., Chang, T. C., Su, I. J., Wang, J. R., Chang, C. F.*, Fut. Med. Chem. 2011, 3, 283-296.
  3. Rapid Characterization of Sugar-Binding Specificity by In-Solution Proximity Binding with Photosensitizers. Chang, C. F.*, Pan, C. F., Lin, C. N., Wu, I. L., Wong, C. H.,and Lin, C. H., Glycobiol., 2011, 21, 895-902.
  4. Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. Cheng, Y. L., Huang, W. C., Chen, C. L., Tsai, C. C., Wang, C. Y., Chiu, W. H., Chen, Y. L., Lin, Y. S., Chang, C. F.*, and Lin, C. F.* Biochem. Biophys. Res. Comm., 2011, 412, 334-340.
  5. The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen. Kuo, C. H., Chen, P. C., Chang, B. I., Sung, M. C., Shi, C. S., Chang, C. F., Shi, G. Y., Wu, H. L. Blood, 2012, 119, 1302-1313.
  6. Characterization of glycan binding specificities of influenza B viruses with correlation to hemagglutinin genotypes and clinical manifestations. Wang, Y. F., Chang, C. F., Chi, C. Y., Wang, H. C., Wang, J. R., Su, I. J. J. Med. Virol., 2012, 84, 679-685. (co-first author)
  7. Receptor binding surveillance of influenza clinical isolates. Wang, Y. F., Lao, W. Y., Kuo, Y. D., Guu, S. Y., Wang, H. C., Lin, C. H., Wang, J. R., Su, I. J. and Chang, C. F.*, Fut. Virol., 2012, 7, 621-633.
  8. Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells. Su, P. Y., Liu, Y. T., Chang, H. Y., Huang, S. W., Wang, Y. F., Yu, C. K., Wang, J. R. and Chang, C. F.*, BMC Microbiol., 2012, 12, 162.
  9. Identification of novel tumor markers for oral squamous cell carcinoma using glycoproteomic analysis. Chen, Y. T., Chong, Y. M., Kasten F. H., Tsai, H. W., Ho, C. L., Chen, Y. L., Chang, C. F.*, Clin. Chim. Acta, 2013, 420, 45-53.
  10. Anterior gradient 2: a novel tumor marker overexpressed in metastatic oral cancer. Chen, Y. T., Ho, C. L., Chen, P. K., Chen, Y. L., Chang, C. F.*, Cancer Lett., 2013, 339, 270-278.
  11. Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with lewis y on endothelial cells. Lin, W. L., Chang, C. F., Shi, C. S., Shi, G. Y., Wu, H. L., Arterioscler. Thromb. Vasc. Biol., 2013,33, 2366-2373.
  12. Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis. Chen, P. K., Chang, B. I., Juo, C. H., Chen, O. S., Cho, C. F., Chang, C. F., Shi, G. Y., Wu, H. L., FASEB J., 2013, 11, 4520-4531.
  13. Galectin-3 Silencing Inhibits Epirubicin-Induced ATP Binding Cassette Transporters and Activates the Mitochondrial Apoptosis Pathway via β-Catenin/GSK-3β Modulation in Colorectal Carcinoma.Lee, Y. K., Lin, T. H., Chang, C. F.*, Lo, Y. L.*, PLoS One, 2013, 8, e82478.
  14. Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment. Chen, C. K., Yang, C. Y., Hua, K. T., Ho, M. C., Johansson, G., Jeng, Y. M., Chen, C. N., Chen, M. W., Lee, W. J., Su, J. L., Lai, T. C., Chou, C. C., Ho, B. , C., Chang, C. F., Lee, P. H., Chang, K. J., Hsiao, M., Lin, M. T., Kuo, M. L., Hepatol., 2014, 59, 974-985.