首頁師資〉專/兼任師資專長

張權發

張權發 (Chang, Chuan-Fa, Ph.D.)

醫技所    副教授    分機:5796            E-mail: affa@mail.ncku.edu.tw

個人網頁:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

研究興趣:

  1. 利用醣質體蛋白體學方法研究腸病毒71型之致病機轉。
  2. 以醣質體及蛋白質體方法尋找癌細胞上新型醣類癌症標記。
  3. 研究醣類轉移酵素在癌細胞生長及轉移所扮演的角色。
  4. 醣類微矩陣晶片(Carbohydrate Microarray)製作及研究應用。

近五年代表作:

  1. Kuo CH, Chen PK, Chang BI, Sung MC, Shi CS, Lee JS, Chang CF, Shi GY, Wu HL. The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen. Blood. 2012;119: 1302-1313.
  2. Wang YF, Chang CF, Chi CY, Wang HC, Wang JR, Su IJ. Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features. J Med Virol. 2012;84: 679-685. (co-first author)
  3. Wang YF, Lao WY, Kuo YD, Guu SY, Wang HC, Lin CH, Wang JR, Su IJ, Chang CF*. Receptor binding surveillance of influenza clinical isolates. Future Virology. 2012;7: 621-622.
  4. Su PY, Liu YT, Chang HY, Huang SW, Wang YF, Yu CK, Wang JR, Chang CF*. Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells. BMC Microbiol. 2012;12: 162.
  5. Chen YT, Chong YM, Cheng CW, Ho CL, Tsai HW, Kasten FH, Chen YL, Chang CF*. Identification of novel tumor markers for oral squamous cell carcinoma using glycoproteomic analysis. Clin Chim Acta. 2013;420: 45-53.
  6. Chen YT, Ho CL, Chen PK, Chen YL, Chang CF*. Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer. Cancer Lett. 2013;339: 270-278.
  7. Lin WL, Chang CF, Shi CS, Shi GY, Wu HL. Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with Lewis Y on endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33: 2366-2373.
  8. Chen PK, Chang BI, Kuo CH, Chen PS, Cho CF, Chang CF*, Shi GY, Wu HL. Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis. FASEB J. 2013;27: 4520-4531.
  9. Lee YK, Lin TH, Chang CF*, Lo YL*. Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via beta-catenin/GSK-3beta modulation in colorectal carcinoma. PLoS One. 2013;8: e82478.
  10. Chen CK, Yang CY, Hua KT, Ho MC, Johansson G, Jeng YM, Chen CN, Chen MW, Lee WJ, Su JL, Lai TC, Chou CC, Ho BC, Chang CF, Lee PH, Chang KJ, Hsiao M, Lin MT, Kuo ML. Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment. Hepatology. 2014;59: 974-985.
  11. Su PY, Wang YF, Huang SW, Lo YC, Wang YH, Wu SR, Shieh DB, Chen SH, Wang JR, Lai MD, Chang CF*. Cell surface nucleolin facilitates enterovirus 71 binding and infection. J Virol. 2015;89: 4527-4538.
  12. Lin WL, Lin YS, Shi GY, Chang CF*, Wu HL*. Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor. PLoS One. 2015;10: e0120162.
  13. Lin WL, Guu SY, Tasi CC, Prakash E, Viswaraman M, Chen HB, Chang CF*. Derivation of cinnamon blocks leukocyte attachment by interacting with sialosides. PLoS One. 2015;10: e0130389.
  14. Cheung SK, Chuang PK, Huang HW, Hwang-Verslues WW, Cho CH, Yang WB, Shen CN, Hsiao M, Hsu TL, Chang CF, Wong CH. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells. Proc Natl Acad Sci U S A. 2016; 113:960-965.
  15. Lin WL, Chen CC, Shi GY, Ma CY, Chang CF*, Wu HL. Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewisy. Immunol Cell Biol. 2016, doi: 10.1038/icb.2016.110.