首頁師資〉教師指導學生

張 玲

  (Chang, Christina Ling, Ph.D.)                                

分子醫學研究所教授分機:3615  E-mail: clchang@mail.ncku.edu.tw

個人網址: http://imm.med.ncku.edu.tw/cl.htm

 

研究興趣

基因不穩定(genome instability)包含微衛星體不穩定(microsatellite instability, MSI),是癌症發生與惡化(cancer development and progression)的主要原因。若有腫瘤移轉(tumor metastasis),百分之九十的癌症病人將會面臨死亡,除非有更有效的治療法。為了降低癌症發生率與死亡率,本實驗室以大腸癌(colorectal cancer)與兒童神經母細胞瘤(neuroblastoma)為癌症模型,積極從事下列兩大方向的研究。

1. 癌症預防 (cancer prevention): 探討發炎、化療如何導致大腸癌細胞與斑馬的腸中出現MSI,並篩選有效藥物以抗發炎、化療所導致之MSI。

2. 腫瘤轉移的分子機制:  NDP kinase A/NM23-H1如何調控兒童神經母細胞瘤的轉移及神經的分化?

專利l  Dual-fluorescent MSI reporter plasmid and cell model harboring the MSI reporter plasmid. Inventor: Chang CL. Republic of China Patent #I421497 (2014~2031)

近五年代表作

  1. Li I-C, Chiu C-Y, Wu C-L, Chi J-Y, Jian S-R, Wang S-W, and Chang CL. (2014) A dual-fluorescent reporter system facilitates identification of thiol compounds that suppress oxidative frameshift mutations . Free Radic Biol Med 69:86-95.
  2. Maity JP, Nath B, Kar S, Chen C-Y, Banerjee S, Jean J-S, Liu M-Y, Centeno JA, Bhattacharya P, Chang CL andSantra SC.  Arsenic-induced health crisis in peri-urban Moyna and Ardebok villages, West Bengal, India: an exposure assessment study. Environ Geochem Health 34:563-74, 2012.
  3. Lee JW, Liao P-C, Young K-C, Chang CL, Chen SSL, Chang TT, Lai M-D and Wang S-W.  Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature Hepatitis C virus core protein. J Proteome Res 10: 4522-34, 2011.
  4. Chang HH, Lee H, Hu MK, Tsao PN, Juan JF, Huang MC, Shih YY, Wang BJ, Jeng YM, Chang CL, Huang SF, Tsay YG, Hsieh FJ, Lin KH, Hsu WM and Liao YF.  Notch1 expression predicts an un-favorable prognosis and serves as a therapeutic target of patients with neuroblastoma. Clin Cancer Res 16:4411-4420, 2010.