首頁師資〉專/兼任師資專長

鄧景浩

鄧景浩 (Teng, Ching-Hao, Ph.D.)                            

分子醫學研究所 副教授 分機:4595  E-mail: chteng@mail.ncku.edu.tw

專長  細菌遺傳及致病機制分子生物學

研究興趣

由於抗生素濫用,新的抗藥性細菌不斷產生。近年來陸續發現帶有多重抗藥性的"超級細菌"。這類抗藥性細菌出現的速度已超越新型抗生素的研發速度,再加上因為人類旅行日漸便利的推波助瀾,這類細菌也快速的散佈全球。這種狀況已經對於醫學界以抗生素來控制感染性疾病的方式帶來隱憂,也對人類健康造成嚴重威脅。因此,對於致病性細菌發展新的預防以及治療策略刻不容緩。

本實驗室的長程目標就是要發展出新的預防及治療策略以對抗不斷演化的致病性細菌。為達此目標,我們從了解細菌致病的機轉著手。因為在了解了致病性細菌入侵人類的過程中如何和宿主交互作用以逃離免疫系統攻擊及獲得生存所需的養分,將有助於找出可能的切入點。致病性大腸桿菌是最常見的人類致病性細菌之一。而且大腸桿菌也是至今為止,人類研究最多的細菌。因此,我們以致病性大腸桿菌為模型,進行其致病機轉研究。而現今,實驗室以研究造成新生兒腦膜炎的K1莢膜大腸桿菌以及泌尿道致病性大腸桿菌為主。

要引起新生兒腦膜炎,K1莢膜大腸桿菌須先在血流中增殖達到一定數目才能穿越血腦障壁進入中樞神經系統。我們正在研究此細菌如何躲避人類血流中的免疫系統的擊殺而繼續增殖,以及它如何和構成血腦障壁的腦微血管內皮細胞交互作用達到穿越血腦障壁的目的。泌尿道致病性大腸桿菌會感染膀胱以及腎臟。在感染過程中,此菌會入侵到泌尿道上皮細胞、抑制宿主免疫反應以及造成細胞凋亡。實驗室正在研究這些反應的機制。

近五年代表作

1. W.C. Huang, C.Y. Lin, M. Hashimoto, C. S. Chen, J. J. Wu, M. C. Wang, Ching-Hao Teng. 2020/1. The role of the bacterial protease Prc in the pathogenesis of extraintestinal pathogenic Escherichia coli. Journal of Biomedical Science . 27 (1), 14-35

2. H. Y. Li,corresponding, C.Y. Kao, W. H. Lin, P. X. Zheng, J. J. Yan, M. C. Wang, Ching-Hao Teng, C. C. Tseng, J. J. Wu. 2018/7. Characterization of CRISPR-Cas systems in clinical Klebsiella pneumoniae isolates uncovers tts potential association with antibiotic susceptibility. Frontiers in Microbiology. 9:1595

3. M. Hashimoto, H. Matsushima, P.I. Suparthana, H. Ogasawara, H. Yamamoto, Ching-Hao Teng, J. Sekiguchi. 2018/3. Digestion of peptidoglycan near the cross-link is necessary for the growth of Bacillus subtilis. Microbiology. 164 (3) 299-307

4. M.Y. Su, N. Som, C.Y. Wu, S. C. Su, Y. T. Kuo, L. C. Ke, M. R. Ho, S. R. Tzeng, Ching-Hao Teng, D. Mengin-Lecreulx, M. Reddy.  C. I. Chang. 2017/12. Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nature Communications.8:1516-1528.

5. Kao CY, Wu HM, Lin WH, Tseng CC, Yan JJ, Wang MC, Ching-Hao Teng, Wu JJ. 2016/8. Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015. Scientific reports, 6, 32281 (SCI).

6. Kuo CJ, Chen JW, Chiu HC, Ching-Hao Teng, Hsu TI, Lu PJ, Syu WJ, Wang ST, Chou TC, Chen CS (2016, Aug). Mutation of the Enterohemorrhagic Escherichia coli Core LPS Biosynthesis Enzyme RfaD Confers Hypersusceptibility to Host Intestinal Innate Immunity In vivo. Frontiers in cellular and infectionmicrobiolog, 6, 82 (SCI).

7. Wang Y.H., Chen H. M., Yang Y. H., Yang T. H., Ching-Hao Teng , Chen C. L., Chu C, Chiu C. H. 2014/12.Clinical and microbiological characteristics of recurrent group B streptococcal infection among non-pregnant adults.International Journal of Infectious Diseases 26: 140-5 (SCI)

8. Y. W. Chen*, Ching-Hao Teng*, Y. H. Ho, T. Y. Ho, W. C. Huang, M. Hashimoto, I. Y. Chiang, and C. S. Chen. 2014/6. Identification of bacterial factors involved in type 1 fimbria expression using an Escherichia coli K12 proteome chip. Molecular and Cellular Proteomics 13:1485-1494. (SCI). *Equal contribution to first authors.

9. W. H. Lin, C. Y. Kao, D. C. Yang, C. C. Tseng, A. B. Wu,Ching-Hao Teng, M. C. Wang J. J. Wu. 2014/9. Clinical and microbiologic characteristics of Klebsiella pneumoniae from community-acquired recurrent urinary tract infections. European journal of clinical microbiology & infectious diseases 33:1533-1539. (SCI).