首頁師資〉教師指導學生

鄭宏祺

鄭宏祺 (Cheng, Hung-Chi, Ph.D.)

生化所副教授   分機:5544      E-mail: hungchi@mail.ncku.edu.tw 

研究興趣:

  1. 癌症轉移所需之粘著分子(Adhesion molecules)方面的研究
  2. 尋找尚未被發現的臟器特異的粘著分子—食道癌,大腸直腸癌,肝癌,鼻咽癌等
  3. 設法阻斷癌症細胞 (fibronectin)及內皮細胞 (dipeptidyl peptidase IV[DPP IV]) 之間的粘著反應,使得轉移無從發生
  4. 探討由癌症細胞/內皮細胞粘著所刺激導致的後粘著反應(post-adhesion events)
  5. CD26 (DPP IV) 在癌症免疫學及免疫治療上之重要性與應用。 

近五年代表作:

  1. Tsung-Cheng Lin, Cheng-Han Yang, Li-Hsin Cheng, Wen-Tsan Chang, Yuh-Rong Lin and Hung-Chi Cheng* (2019, Dec). Fibronectin in Cancer: Friend or Foe. Cells, 9(1), 27. (2018 JCR IF=5.656)(Rank=40/193(20.7%),Cell biology).
  2. Yu-Shiuan Wang, Hong-Tai Tzeng, Chung-Han Tsai, Hung-Chi Cheng, Wu-Wei Lai, Hsiao-Sheng Liu, Yi-Ching Wang(2018, Nov). VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function. Cancer Letters, 28; 437: 79-88. (2017 JCR IF=6.491)(Rank=29/223(13%),Oncology)
  3. Po-Lin Tseng, Wei-Hsuan Wu, Tsung-Hui Hu, Chih-Wei Chen, Hung-Chi Cheng, Chien-Feng Li, Wen-Hui Tsai, Hui-Ju Tsai, Meng-Che Hsieh, Jiin-Haur Chuang and Wen-Tsan Chang.(2018, Feb). Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect. Scientific Report, 15; 8(1):3081. (2017 JCR IF=4.122) (Rank=12/64(18.75%), Multidisciplinary Sciences)
  4. Rong-Jane Chen, Hsiao-Che Kuo, Li-Hsin Cheng, Yu-Hsuan Lee, Wen-Tsan Chang, Bour-Jr Wang, Ying-Jan Wang, Hung-Chi Cheng* (2018, Jan). Apoptotic and Nonapoptotic Activities of Pterostilbene Against Cancer. International Journal of Molecular Sciences, 19, 287. (2017 JCR IF=3.687) (Rank=52/171(30.41%) Chemistry, Multidisciplinary).
  5. Tsung-Cheng Lin, Ying-Chih Liao, Wen-Tsan Chang, Cheng-Han Yang, Li-Hsin Cheng, Megan Cheng, Hung-Chi Cheng* (2018, Jun). The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues. The Journal of Visualized Experiments, (136), e56761, (2017 JCR IF=1.184) (Rank=31/64 (48.43%) Multidisciplinary Sciences).
  6. Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai,Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, and Ruey-Hwa Chen (2017, Aug). Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment. Journal of Clinical Investigation, 127(8):2982-2997. (2017 JCR IF=13.251) (Rank=4/133 (3.01%) Medicine, Research and Experimental)
  7. Yi-Ching Wang, Hong-Tai Tzeng, Chung-Han Tsai, Yi-Ting Yen, Hung-Chi Cheng, Yi-Chieh Chen, Shih-Wen Pu, Yu-Shiuan Wang, Yan-Shen Shan, Yau-Lin Tseng, Wu-Chou Su, Wu-Wei Lai and Li-Wha Wu (2017, May). Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis. Clinical Cancer Research, 23(9):2335-2345. (2017 JCR IF=10.199) (Rank=12/222 (5.41%) Oncology)
  8. Ying-Jan Wang, Jing-Fang Lin, Li-Hsin Cheng, Wen-Tsan Chang, Ying-Hsien Kao, Ming-Min Chang, Bour-Jr Wang and Hung-Chi Cheng* (2017, Mar). Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis. Journal of Hematology & Oncology, 10(1):72. (2017 JCR IF=7.333) (Rank=6/71 (8.45%) Hematology)
  9. Ying-Hua Chang & Yi-Jen Chiu & Hung-Chi Cheng & Fang-Ju Liu & Wu-Wei Lai & Hsiao-Jen Chang & Pao-Chi Liao (2015, May). Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma. Tumor Biology, 36(5):3957-67. (2016 JCR IF=3.65) (Rank=81/217 (37.32%) Oncology)
  10. Chih-Ling Huang, Wen-Tai Chiu, Yu-Lung Lo, Chin-Ho Chuang, Yu-Bin Chen, Shu-Jing Chang, Tung-Ting Ke, Hung-Chi Cheng and Hua-Lin Wu (2015, Feb). Optical detection of metastatic cancer cells using a scanned laser pico-projection system. Laser Physics Letters, 12 (2015) 035602. (2017 JCR IF=2.24) (Rank=37/94 (39.36%) Optics)
  11. Chung-Han Tsai, Hung-Chi Cheng, Yu-Shiuan Wang, Pinpin Lin, Jayu Jen, I-Ying Kuo, Ying-Hua Chang, Pao-Chi Liao, Ruey-Hwa Chen, Wei-Chien Yuan, Han-Shui Hsu, Muh-Hwa Yang, Ming-Ta Hsu, Chu-Yi Wu, Yi-Ching Wang. (2014, Sep). Small GTPase Rab37 targets tissue inhibitor of etalloproteinase 1 for exocytosis and thus suppresses tumor metastasis. Nature communications, 5:4804. (2017 JCR IF=12.353) (Rank=3/64 (4.68%) Multidisciplinary Sciences)