首頁師資〉專/兼任師資專長

鄭宏祺

鄭宏祺  (Cheng, Hung-Chi, Ph.D.)

生化所副教授   分機:5544      E-mail: hungchi@mail.ncku.edu.tw

個人網頁:http://www.ncku.edu.tw/~biochem/profs/HCCheng/introduc.htm  

研究興趣

1.  癌症轉移所需之粘著分子(Adhesion molecules)方面的研究

2.  尋找尚未被發現的臟器特異的粘著分子—食道癌,大腸直腸癌,肝癌,鼻咽癌等

3.  設法阻斷癌症細胞 (fibronectin)及內皮細胞 (dipeptidyl peptidase IV[DPP IV]) 之間的粘著反應,使得轉移無從發生

4.  探討由癌症細胞/內皮細胞粘著所刺激導致的後粘著反應(post-adhesion events)

5.  CD26 (DPP IV) 在癌症免疫學及免疫治療上之重要性與應用。

 

近五年代表作

1.  Huang L, Cheng HC, Isom R, Chen CS, Levine R, Pauli BU. (2008) PKCε mediates polymeric fibronectin assembly on the surface of suspended (blood-borne) rat breast cancer Cells to promote pulmonary metastasis. J. Biol. Chem. 283: 7617-7627.

2.  Hung TT, Wu JY, Liu JF, and Cheng HC*. (2009)Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion.  FEBS J. 276: 6548–6559. * means corresponding author.

3.  Chung-Chi Hsu, Chi-Wu Chiang, Hung-Chi Cheng, Wen-Tsan Chang, Cheng-Yang Chou, Hung-Wen Tsai, Chung-Ta Lee, Zorn-Huah Wu, Ting-Yuan Lee, Anning Chao, Nan-Haw Chow, and Chung-Liang Ho.Identifying LRRC16B as an Oncofetal Gene with Transforming Enhancing Capability using a Combined Bioinformatics and Experimental Approach. Oncogene. 2011; 30: 654-667. (C-W Chiang, H-C Cheng, and W-T Chang contributed equally to this manuscript)

4.  Jia-Yang Chen, Ying-Chieh Sun, Szu-Chi Wang, Hsueh-Fen Juan, Li-Wha Wu, Wen-Shan Li*, Hung-Chi Cheng*, and Yi-Ching Wang*.A novel sialyltransferase inhibitor suppresses cancer cell metastasis by inhibiting FAK/paxillin and anti-angiogenesis signaling. Cancer Research. 2011; 71: 473-483. * means corresponding author.

5.  Fang-Yi Lo,Yi-Hung Carol Tan, Hung-Chi Cheng, Ravi Salgia, and Yi-Ching Wang. An E3 ubiquitin ligase c-CBL: a new therapeutic target of lung cancer in cell and animal models. Cancer 117 (2011) 5344-5350.

6.  Chung-Hsi Hsing, Hung-Chi Cheng, Yu-Hsiang Hsu, Chien-Hui Chan, Ching-Hua Yeh, Chien-Feng Li, and Ming-Shi Chang. Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clin Cancer Res. 18 (2012)713-725.

7.  Shieh JM, Wei TT, Tang YA, Huang SM, Wen WL, Chen MY, Hung-Chi Cheng, Salunke SB, Chen CS, Lin P, Chen CT, Wang YC. (2012) Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. PLoS One. 2012;7(1):e30240. Epub 2012 Jan 18.

8.  Chang YH, Lee SH, Liao IC, Huang SH, Hung-Chi Cheng, Liao PC. (2012) Secretomic analysis identifies A1AT as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells. Mol Cell Proteomics., 11(11):1320-39.

9.  Lo FY, Chen HT, Hung-Chi Cheng, Hsu HS, Wang YC.( 2012)  Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer. Lung Cancer., 77(3):585-92.

10. Tzu-Yu Weng, Wen-Tai Chiu, Hsiao-Sheng Liu, Hung-Chi Cheng, Meng-Ru Shen, David B. Mount, Cheng-Yang Chou. Glycosylation regulates the function and membrane localization of KCC4. Biochimica et Biophysica Acta 1833 (2013) 1133–1146.