PirB is a functional receptor for myelin inhibitors of axonal regeneration (Science, 2008, 322:967-970)

報告日期: 2009/05/12
報告時間: 16:05/16:55
報告學生: 楊正昌
講評老師: 黃阿敏
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/980512-2.pdf

PirB is a functional receptor for myelin inhibitors of axonal regeneration

Science 322, (2008)

 

Speaker: Cheng-Chang Yang

Commentator: A-Min Huang Ph. D.

Date: 05-12-2009

Time: 16:05- 16:55

Place: Room No. 602

 

Abstract:

 

Nervous system injuries and neurological diseases often result in loss of sensation and paralysis that are irreversible. Long cellular processes, the axon, are unable to regrowth because an unfavorable milieu formed a barrier to regeneration after injury in central nervous system. Several proteins in myelin like Nogo, MAG and OMgp inhibited axon outgrowth in vitro and bind to glycosylphosphatidylinosito-anchored Nogo receptor (NgR). Previously study indicated inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in adult CNS. The NgR deletion has only a modest disinhibitory effect, suggested that the other receptor may exist. In this investigation, expression cloning was used to find paired immunoglobulin like receptor B (PirB) which was high-affinity receptor for Nogo, MAG and OMgp. Interfere the PirB activity by either antibody or genetic methods partially rescued neurite inhibition by Nogo, MAG, OMgp and myelin in neurons. Blocking both NgR and PirB activity caused almost-complete rescue from myelin inhibition. These results indicated that PirB was a mediator involving in regeneration block. According to this finding, PirB blocking probably provided a potential therapy for axon regeneration.

 

Reference:

Kim W. Y., Snider W. D. (2008) Neuroscience. Overcoming inhibitions. Science 322, 869-872.

Wang K. C, Koprivica V., Kim J. A., Sivasankaran R., Guo Y., Neve R. L., He Z. (2002) Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941-944.