Systemic signals regulate ageing and rejuvenation of blood stem cell niches (Nature, 2010, 463:495-500)

報告日期: 2010/03/16
報告時間: 15:10/16:00
報告學生: 王冠傑(英文報告)
講評老師: 蔣輯武
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990316-1.pdf

Systemic signals regulate ageing and rejuvenation of blood stem cell niches

Shane R. Mayack, Jennifer L. Shadrach, Francis S. Kim and Amy J. Wagers

Nature. 463:495–500 (2010).

 

Speaker   : 王冠傑

Commentator  : 蔣輯武  老師

Date: 2010.3.16

Time: 15:10-16:00

Room: 602

 

Abstract:

    Stem cells appear to lose their normal function such as self-renewal and appropriate lineage-specific differentiation during ageing. The maintenance and survival of stem cells is regulated by many intrinsic factors from their local microenvironment. In the haematopoietic system, aged haematopoietic stem cells (HSCs) have been shown to increase HSC frequency and number in bone marrow (BM), reduce reconstitution of peripheral leukocytes, exhibit biased differentiation potential, and eventually contribute to aged associated blood diseases. However, it is not clear whether age-related defects in niche cells can affect HSC function and be sequentially related to disease formation. In this study, authors used parabiosis model to test whether systemic factors can alter HSC and/or function of osteoblastic niche cell. The results showed that exposing an old mouse to the blood of a young one restores function of HSC and osteoblastic niche cell. Moreover, inhibition of insulin like growth factor-1 (IGF-1) in aged niche cells was found to rejuvenate HSCs, indicating IGF-1 signaling in aged osteoblastic niche cells might impair the normal function of HSCs, and potentially lead to subsequent haematopoietic dysfuction. This study might provide new strategies to improve circulatory environment to maintain appropriate function of both niche cells and stem cells in blood-related diseases.

References:

1.  Jones, D. L. and Wagers, A. J. No place like home: anatomy and function of the stem cell niche. Nature Rev. Mol. Cell Biol. 9, 11–21 (2008).

2.  Silva, H. and Conboy, I.M., Aging and stem cell renewal (July 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.11.1, http://www.stembook.org.