Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats (Plos One, 2008, 3(5);e2170:1-13)

報告日期: 2009/05/22
報告時間: 15:10/16:00
報告學生: 葉哲銘(英文報告)
講評老師: 黃阿敏
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/980522-1.pdf

Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

Plos One 3(5) e2170, 2008

 

Speaker: Che-Ming Yeh

Commentator: Dr. A-min Huang

 

Abstract

Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. Prenatal restraint stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Sexually dimorphic effects of prenatal stress have not carefully investigated. Only a few studies have addressed the gender effect in the out come of prenatal restraint stress. The goal of the paper was to correlate behavioral responses with neurobiological data focused on the hippocampus region given to be a PRS target. Three neuronal target have been examined (1) glutamate receptor, (2) BDNF level, (3) and neurogenesis in the dentate gyrus (DG). In brief, adult male rats show increased anxiety-like behavior (reduced in female), an increase on the expression level of BDNF and pro-BDNF (no change in female). In hippocampal neurogenesis, a reduction was observed in male rats (not in female). This study examined that PRS reduced mGlu 2/3 receptor expression in both male and female rats. But it showed no effect on the expression of mGlu1a or mGlu5 receptors in female rats. Interestingly, PRS induced a reduction in the expression of mGlu5 receptor in male rats. By using chemical compound to stimulate PI hydrolysis, it is only affected slightly by PRS subjected to male rats in dorsal hippocampus. Over all, PRS induces inverse effects in male versus female: improvement in female, impairment in male. These data are not in line with the classic relationship between correlative changes in hippocampus and learning abilities in a so-called hippocampus-dependent response. The underlay mechanism remains to answered.

 

Reference

Bowman RE, MacLusky NJ, Sarmiento Y, Frankfurt M, Gordon M, Luine VN. 2004. Sexually dimorphic effects of prenatal stress on cognition, hormonal responses, and central neurotransmitters. Endocrinology 145(8):3778-3787.

De Blasi A, Conn PJ, Pin J, Nicoletti F. 2001. Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol Sci 22(3):114-120.