Tumor self-seeding by circulating cancer cells (Cell, 2009, 139:1315-1326)

報告日期: 2010/03/19
報告時間: 17:10/18:00
報告學生: 梁鎮顯(英文報告)
講評老師: 鄭宏祺
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990319-3.pdf

Tumor Self-Seeding by Circulating Cancer Cells

 

Mi-Young Kim, Thordur Oskarsson, Swarnali Acharyya, Don X. Nguyen, Xiang H.-F. Zhang, Larry Norton, and Joan Massague

Cell 139: 1315–1326, 2009

 

Speaker: 梁鎮顯

Commentator: 鄭宏祺 老師

Time: 2010/03/19  17:10-18:00

Place: Room 602

 

Abstract:

When cancer cells arised as a benign tumor from epithelium, most of them eventually will grow in malignancy and turn into metastatic cancer cells.

In order to spread, some cancer cells from the primary tumor must break away, travel to secondary site through circulation.  However, to colonize successfully at distant organs, circulating tumor cells must acquire the abilities to leave circulation and adapt to the new microenvironment. In this study, the authors reasoned that circulating tumor cells should require little adaptation to survive and grow at tumors from their primary organs. They demonstrate that circulating cancer cells can reinfiltrate tumors at their organs of origin to promote the growth of the primary tumors. In the breast cancer and melanoma models, the recruitment of circulating cancer cells to their primary organs is mediated by tumor-derived cytokines interleukins 6 and 8, and the infiltration of seeder cells through mediated matrix metalloproteinase 1 and the actin bundling protein Fascin-1. The authors also show that tumor self-seeding could promote primary tumor growth, enhance angiogenesis, and recruit stromal components. This recruitment is mediated by the cytokine CXCL1 produced by the seeder cells.

 

References:

1.   Chiang, A.C., and Massague , J. (2008). Molecular basis of metastasis. N. Engl. J. Med. 359, 2814–2823.

2.   Norton, L., and Massague, J. (2006). Is cancer a disease of self-seeding? Nat. Med. 12, 875–878.

3.  Carmeliet, P., and Jain, R.K. (2000). Angiogenesis in cancer and other diseases. Nature 407, 249–257.