Platelets amplify inflammation in arthritis via collagen-dependent microparticle production (Science, 2010, 327:580-583)

報告日期: 2010/10/26
報告時間: 15:10/16:00
報告學生: 李原聰
講評老師: 王崇任
附件下載:

Full text: http://basicmed.med.ncku.edu.tw/admin/up_img/991026-1.pdf

Platelets Amplify Inflammation in Arthritis via collagen-Dependent Microparticle Production

Eric Boilard et al.

Science 327, 580 (2010)

 

Student: 李原聰

Commentator: 王崇任 醫師       

Time: 15:10-16:00, Oct. 25, 2010

Place: 602教室

 

Platelets are well-known of its blood-clotting and wound-healing functions. It is a highly abundant type of hematopoietic cells, the size is about 1-4 micrometers. Other than those well-known functions, platelets are also reported to play a very important role during inflammation. The author found a large amount of platelet-derived microparticles in the synovial fluid of rheumatoid arthritis patients, much more than of osteoarthritis or other inflammatory arthritides ( juvenile idiopathic arthritis, psoriatic arthritis and gout ). They also used antibody to deplete platelets in K/BxN rheumatoid arthritis mice model, the results show that platelets are important in the pathology in rheumatoid arthritis. Furthermore, they used knockout mice and pharmaceutical drugs to identify the main reason of platelets activation. They found that the fibroblast-like synoviocytes can trigger the release of platelets microparticles by the interaction of collagen on extracellular matrix and the collagen receptor GPV on platelets. In return, the activated microparticles can also activate fibroblast-like synoviocytes by membrane bound IL-1. The activation makes FLS secrete IL-6 and IL-8 to amplify the inflammation in joints. This article points out that platelet microparticles is a new type of proinflammatory factors in rheumatoid arthritis. It also provides a strong evidence that GPVI could be a novel therapeutic target of rheumatoid arthritis since human loss GPVI gene remains healthy.

 

Reference:

1. Platelets. J. N. George, Lancet 355, 1531 (2000).

2. Platelet Activation and Atherothrombosis. G. Davì, C. Patrono, N. Engl. J. Med. 357, 2482 (2007).