Chromosomal instability, telomere shortening, and inactivation of p21WAF1/CIP1 in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis (Modern Pathology, 2009, 22:1121-1131)

報告日期: 2010/10/26
報告時間: 16:00/16:50
報告學生: 斐武明皇(英文報告)
講評老師: 楊孔嘉
附件下載:

Full text: http://basicmed.med.ncku.edu.tw/admin/up_img/991026-2.pdf

Chromosomal instability, telomere shortening, and inactivation
of p21WAF1/CIP1 in dysplastic nodules of hepatitis B virus-associated
multistep hepatocarcinogenesis

 

(Yoon Hee Lee, Bong-Kyeong Oh, Jeong Eun Yoo, So-Mi Yoon, Jinsub Choi, Kyung Sik Kim and Young Nyun Park)

Modern Pathology 2009, 22, 1121 -1131

 

Speaker: 裴武明皇 

Commentator: 楊孔嘉

Time: 16:00 – 16:50, Oct 26, 2010

Place: Room 602

 

Abstract:

Hepatocellular carcinoma (HCC) is one of most common causes of cancer related deaths and the prognosis of pateints is very poor. So, understanding clearly about molecular pathogenesis of hepatocarcinogenesis will help diagnosis and treatment of precancerous lesions in the early stage of hepatocarcinogenesis more effective. A systemic assessment of telomere length, chromosomal instability, and inactivation of cell cycle checkpoints in multistep hepatocarcinogenesis has not been done. Therefore, the authors did this study to show the expressions as well as the relationships of telomere length, micronuclei and p21WAF1/CIP1 during hepatitis B virus-associated human multistep hepatocarcinogenesis. This study demonstrated that micronuclei index is increased gradually and telomere length is shoterned gradually during hepatitis B virus-associated human multistep hepatocarcinogenesis. The authors also found that p21WAF1/CIP1 expression is decreased in precancerous as well as cancerous lesions, whereas it is higher in cirrhotic liver than normal liver. The p21WAF1/CIP1 expression was correlated positively with telomere length. From these results, the authors showed that telomere shortening, chromosomal instability and inactivation of p21WAF1/CIP1 checkpoint occur in both low-grade and high-grade dysplastic nodules, which are precancerous lesions of human multistep hepatocarcinogenesis. This paper indicated that the cooperation of telomere shortening, chromosomal instability and inactivation of p21WAF1/CIP1 checkpoint is considered to be critical for malignant transformation during hepatitis B virus associated multistep hepatocarcinogenesis.

 

Reference:

1.    Villanueva A. et al. Hepatocellular carcinoma: Novel molecular approaches for Diagnosis, Prognosis and Therapy. Annual Review of Medicine, 2010, 61: 317-28.

2.    Plentz R.R. et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology, 2007, 45 (4): 968-976.