mTOR signal and hypoxia-inducible factor-1alpha regulate CD133 expression in cancer cells (Cancer Res, 2009, 69(18):7160-7164)

報告日期: 2010/05/25
報告時間: 15:10/16:00
報告學生: 林長霓
講評老師: 賴明德

mTOR signal and hypoxia-inducible factor-1α regulate CD133 expression in cancer cells

Cancer Res 2009; 69: 7160-7164.


Commentator: Lai, Ming-Derg, Ph. D.

Speaker: Lin, Chang-Ni

Date: 2010/5/25



  CD133 is a cancer stem cell marker generally acknowledged in the present research, but the mechanism regulating the expression of CD133 in cancer cells still unclear. In this study, they found CD133 up-regulation when inhibition the mTOR signaling and down-regulation by hypoxia-inducible factor-1α (HIF-1α). When the oxygen supply is depleted, the cells become hypoxia, results in the expression of HIFs. HIFs including HIF-1α and HIF-1β, they can binding to HRE and regulate lots of gene expression, such as VEGF. The correlations between CD133 and the expressions of HIF-1α was make sure by RNA microarray using clinical gastric cancer samples. In conclusion, these data provide the evidence of regulatory mechanisms of CD133 expression through mTOR pathway and the HIF-1α involvement of the signal. These findings to explain the mechanism of CD133 in gastrointestinal cancer cells, and better understanding of the stemness character of cancer stem cells.



1.    Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.

2.    Jiri N, Marina S, Renata Z, et al. Tumor-initiating cells vs. cancer ‘stem’ cells and CD133: What’s in the name? BBRC 2007; 355: 855-859.