mTOR signal and hypoxia-inducible factor-1alpha regulate CD133 expression in cancer cells (Cancer Res, 2009, 69(18):7160-7164)

報告日期: 2010/05/25
報告時間: 15:10/16:00
報告學生: 林長霓
講評老師: 賴明德
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/990525-1.pdf

mTOR signal and hypoxia-inducible factor-1α regulate CD133 expression in cancer cells

Cancer Res 2009; 69: 7160-7164.

 

Commentator: Lai, Ming-Derg, Ph. D.

Speaker: Lin, Chang-Ni

Date: 2010/5/25

 

Abstract

  CD133 is a cancer stem cell marker generally acknowledged in the present research, but the mechanism regulating the expression of CD133 in cancer cells still unclear. In this study, they found CD133 up-regulation when inhibition the mTOR signaling and down-regulation by hypoxia-inducible factor-1α (HIF-1α). When the oxygen supply is depleted, the cells become hypoxia, results in the expression of HIFs. HIFs including HIF-1α and HIF-1β, they can binding to HRE and regulate lots of gene expression, such as VEGF. The correlations between CD133 and the expressions of HIF-1α was make sure by RNA microarray using clinical gastric cancer samples. In conclusion, these data provide the evidence of regulatory mechanisms of CD133 expression through mTOR pathway and the HIF-1α involvement of the signal. These findings to explain the mechanism of CD133 in gastrointestinal cancer cells, and better understanding of the stemness character of cancer stem cells.

 

Reference

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