Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory (Cell, 2009, 139:814-827)

報告日期: 2010/05/28
報告時間: 15:10/16:00
報告學生: 洪惠琪(英文報告)
講評老師: 黃阿敏

Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory


Cell 139, 814-827 (2009)


Takashi Kitamura, Yoshito Saitoh, Noriko Takashima, Akiko Murayama, Yosuke Niibori, Hiroshi Ageta, Mariko Sekiguchi, Hiroyuki Sugiyama, and Kaoru Inokuchi


Commentator: Huang, A-Min, Ph.D.

Speaker: Hung, Hui-Chi

15:10-16:00, May 28, 2010, Room 602



The hippocampus (HPC) belongs to medial temporal lobe memory system responsible for general declarative memory initially. However, in order to preserve the learning capacity of the HPC, make gradual decay use for the hippocampus-dependency old memories. The HPC-dependency old memory has become progressively dependent on cortical permanent networks. Nevertheless, the mechanisms underlying the gradual decay of memory becomes progressively independent from the HPC remain unknown. In the hippocampus, adult neurogenesis can be continued expression and can be positively and negatively modulation. The authors suppress HPC neurogenesis by X-irradiation and follistatin in a forebrain-specific manner (FSM mice). The result show that decreased neurogenesis is accompanied by a prolonged HPC-dependent period of associative fear memory. Inversely, enhanced neurogenesis by voluntary exercise sped up the decay rate of HPC dependency of memory, without loss of memory. Consistently, decreased neurogenesis facilitated the long-lasting maintenance of rat HPC long-term potentiation in vivo by using DG LTP in freely moving unanaesthetized rats. These results suggest that the level of HPC neurogenesis play a role in determination of the HPC-dependent period of memory in adult rodents. These observations provide a framework for understanding the mechanisms of the HPC-cortical complementary learning systems.



Kee, N., Teixeira, C.M., Wang, A.H., and Frankland, P.W. (2007). Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci. 10, 355–362.