Dopamine controls persistence of long-term memory storage (Science, 2009, 325:1017-1020)

報告日期: 2010/05/28
報告時間: 16:10/17:00
報告學生: 張智華(英文報告)
講評老師: 吳豐森

Dopamine Controls Persistence of Long-term Memory Storage


Rossato JI, Bevilaqua LR, Izquierdo I, Medina JH, Cammarota M.

Science. 325(5943) 1017 - 1020 (2009).


Speaker: Chang, Chih-Hua (張智華)

Commentator: Wu, Fong-Sen, Ph.D.(吳豐森 老師)

Time: 2010.05.28. 16:10 – 17:00

Place: Room 602





Persistence is the most characteristic attribute of long-term memory (LTM). However, little is known about the mechanisms that make some LTMs last longer than others. It is widely accepted that motivational experiences, which trigger transient dopamine-dependent states, tend to be well remembered. The hippocampus that involves the contextual memory formation receives dopaminergic projections from the ventral tegmental area (VTA). Recently it is has been reported that dopamine regulates the expression of brain-derived neurotrophic factor (BDNF). And the authors recently demonstrated that in order to persist, fear LTM requires BDNF expression in the hippocampus 12 hours after training. In this study, the authors examined the role of hippocampal dopamine and the VTA on LTM persistence. In rats, a long-lasting fear LTM declined rapidly when the D1 dopamine receptor antagonist SCH23390 or PKA inhibitor PKI was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intra-CA1 of hippocampus infusion of the D1 agonist SK38393 or 8-bromo-cAMP, a cAMP analog, at the same critical post-training time converted a rapid decaying fear LTM into a persistent one. The data indicated that dopamine in the dorsal CA1 is required during a restricted time window around 12 hours after training for memory persistence, but not for memory formation. This also regulates the expression of BDNF necessary for LTM persistence and requires NMDA-R activity in the VTA immediately and 12 hours after training. Thus, the LTM persistence depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated at definite post-learning time points.


References 1-2

1.  Bekinschtein, P., et al. Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. Neuron 53, 261-277 (2007).

2.  Wise, R.A. Dopamine, learning and motivation. Nat Rev Neurosci 5, 483-494 (2004).