Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens (Biol Psychiatry, 2010, 67:28-35)

報告日期: 2010/06/04
報告時間: 16:20/17:30
報告學生: 曾文郁
講評老師: 黃阿敏
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Environmental Enrichment Produces a Behavioral Phenotype Mediated by Low Cyclic Adenosine Monophosphate Response Element Binding (CREB) Activity in the Nucleus Accumbens

BIOL PSYCHIATRY 2010;67:28–35

 

Speaker: Tseng, Win-Yu (曾文郁)                

Commentator: Huang, A-Min, Ph.D.(黃阿敏 老師)  

Time: 2010.06.04. 16:20~17:30

Place: Room 602

 

Abstract

Environmental factors have been thought to prime for the induction of many mental disorders, including anxiety, depression, and addictions. Therefore, identifying environmental factors underlying susceptibility to drug addiction is primary goal of this study. The authors demonstrated that environmental enrichment altered amphetamine-induced locomotor activity sensitization and -conditioned place preference (CPP). In this study, the authors used several behavioral tasks, including cocaine-induced CPP, self-administration and various anxiety- and depression-related behaviors. They also investigated that underlying molecular mechanisms. Their results showed that enriched condition (EC) rats, compared with isolated condition (IC) rats, exhibited reduced cocaine self-administration but higher cocaine-induced CPP, decreased depression-related behavior but increased anxiety-related behavior, and decreased cyclic adenosine monophosphate response element binding protein (CREB) activity in the nucleus accumbens (NAc). They concluded that environmental enrichment generated phenotype was mediated, at least partly, by decreasing CREB activity in the NAc. Moreover, the authors developed a novel CREB RNAi AAV vector method to knock down levels of endogenous CREB in NAc selectively and reproduced the EC behavioral phenotype.

 

References

1.    T.A. Green, B.J. Gehrke and M.T. Bardo, Environmental enrichment decreases intravenous amphetamine self-administration in rats: Dose-response functions for fixed- and progressive-ratio schedules, Psychopharmacology (Berl) 162 (2002), pp. 373–378.

2.    K.H. Choi, K. Whisler, D.L. Graham and D.W. Self, Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement, Neuroscience 137 (2006), pp. 373–383.