Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction (J Neurosci, 2010, 30:304-315)

報告日期: 2010/06/11
報告時間: 16:20/17:30
報告學生: 陳麗仙
講評老師: 郭余民

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Reduction of Adult Hippocampal Neurogenesis Confers Vulnerability in an Animal Model of Cocaine Addiction

J Neurosci. 2010 Jan 6;30(1):304-15.

Michele A. Noonan, Sarah E. Bulin, Dwain C. Fuller, and Amelia J. Eisch


Speaker: Li-hsien Chen (陳麗仙)

Commentator: Yu-Min Kuo, Ph.D  (郭余民 老師)

Date: 06/11 15:10 – 16:00

Place: Room 602



    Cocaine is a highly addictive psychostimulant which acts primarily by enhancing dopamine neurotransmission and produce neuroadaptations in the hippocampus. Hippocampus formation has been thought to mediate the formation of drug-context conditioning and induce drug-seeking behavior1.  Adult neurogenesis represents one form of hippocampus plasticity regulated by environmental factors, stress and illicit drug use. Interestingly, environmental enrichment, and exercise-enhanced hippocampus neurogenesis have been known to associate with decreased drug-taking and relapse2. In contrast, stress decreased neurogenesis is associated with increased drug-taking and relapse3. These findings, taken together, suggest that reduced hippocampal neurogenesis might lead to increase drug-taking and drug-seeking behavior.

This study aims to test the hypothesis that suppression of adult hippocampal neurogenesis may enhance vulnerability to cocaine addiction and relapse. These authors use cranial irradiation to abolish hippocampal neurogenesis in a rat model. Cocaine self-administration paradigm is used to assess cocaine-taking and cocaine-seeking behavior. The authors find that suppression of adult hippocampal neurogenesis before drug-taking significantly increases cocaine self-administration on both fixed-ratio and progressive-ratio schedules. Likewise, reduction of adult hippocampal neurogenesis significantly enhances resistance to the extinction of cocaine-seeking behavior. Therefore, diminished hippocampal neurogenesis appears to be a risk factor in continuous cocaine-taking and seeking behavior. These authors suggest that therapeutics increasing adult hippocampal neurogenesis may be promising in preventing cocaine addiction and relapse during abstinence.



1.  Canales JJ (2007) Adult neurogenesis and the memories of drug addiction. Eur Arch Psychiatry Clin Neurosci  257:261–270

2.  Smith MA, Schmidt KT, Iordanou JC, Mustroph ML (2008) Aerobic exercise decreases the positive-reinforcing effects of cocaine. Drug Alcohol Depend 98:129 –135.

3.  Mirescu C, Gould E (2006) Stress and adult neurogenesis. Hippocampus 16:233–238.