Lipid accumulation and dendritic cell dysfunction in cancer (Nat Med, 2010, 16:880-886)

報告日期: 2010/09/24
報告時間: 17:10/18:00
報告學生: 翁子洋
講評老師: 張南山
附件下載:

Full Text:  http://basicmed.med.ncku.edu.tw/admin/up_img/990924-3.pdf

Lipid accumulation and dendritic cell dysfunction in cancer

NATURE MEDICINE 2010, 16 , 880–886

 

Speaker: Weng, Tzu-Yang

Commentator: Chang, Nan-Shan, Ph.D

Time: 2010/09/24, 17:00

Place: room 602

 

Abstract:

Dendritic cells (DCs) are professional antigen presenting cells which specializing in acquisition, processing and presenting of antigens to T cells. But in cancer immunity, tumor cells usually result in DCs dysfunction by various tumor­derived factors. However, there is little information about mechanism of DCs dysfunction in cancer. In this study, authors found that DCs from tumor-bearing hosts and subjects were increased lipid accumulation, especially triglycerides (TAG). These phenomena were due to the up-regulation of Msr1 expression, a scavenger receptor, which played the major role in intracellular transportation of lipids in DCs. They also suggested that high lipid content in DCs may have defects in processing of tumor­associated proteins in different experimental models. Treatment with an acetyl­CoA carboxylase inhibitor, TOFA, to block the TAG synthesis also decreased lipid accumulation and reversed the stimulation function of DCs. Combining TOFA with the vaccine resulted in a significant decrease of tumor growth in tumor bearing mice. Taken together, this study showed that immune responses in cancer can be improved by manipulating the lipid levels in DCs.

 

Reference:

1.      Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 16, 880–886 (2010).

2.      The mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 4, 941–952 (2004).

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