Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3 (Nat Immunol, 2011, 12:85-95)

報告日期: 2011/03/22
報告時間: 16:00/16:50
報告學生: 彭佳琇 (英文報告)
講評老師: 楊倍昌

Full text:

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3
Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W.
Nat Immunol. 2011 Jan;12(1):86-95.
Speaker: Jia-Shiou Peng
Commentator: Dr. Bei-Chang Yang
Date: 2011/3/22 16:00-16:50
Place: Room 602
CD4+CD5+Foxp3+ Regulatory T cells (Treg cells) that express the transcription factor Foxp3 are instrumental in the induction and maintenance of peripheral immune tolerance and the regulation of tumor immunity and infec­tion1. DNA-binding inhibitor Id3, a transcrip­tion factor involved in T cell development, growth inhibition of a B cell progenitorsand protection of mice against autoimmune-like Sjögren’s syndrome2. In this study, the authors investigated the Id3 regulated the TGF-b-mediated reciprocal differentiation of Treg cells and TH17 cells. At first, to analyze Treg cell number and Treg function in Id3/ mice. They found that the generation and function of CD4+Foxp3+ Treg cells were defective in Id3/ mice. Next, the authors investigated the molecular mechanisms of Id3 is involved in the TGF-β-induced generation of Foxp3+ Treg cells. They found that E2A can bind to Foxp3 promoter in response to TGFβ treatment. Besides, the extra E2A in the absence of Id3 could induce large amounts of IL-4 that in turn drive GATA-3 expression. Moreover, loss of Id3 in mice leads to more TH17 cells. Subsequently, the authors found that the preferential differentiation of Id3/ cells into TH17 cells during HDM-induced asthma. Collectively, this study demonstrates that Id3 is not only a key regulator of TGF-β-dependent immune responses, able to promote Foxp3 induction and inhibit TH17 differentiation.
1.     Belkaid, Y. & Tarbell, K. Regulatory T cells in the control of host-microorganism interactions. Annu. Rev. Immunol. 27, 551–589 (2009).
2.     Murre, C. Helix-loop-helix proteins and lymphocyte development. Nat. Immunol. 6, 1079–1086 (2005).