CD4+ T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation (Cancer Cell, 2010, 18:485-498)

報告日期: 2011/03/25
報告時間: 16:00/16:50
報告學生: 翁子洋 (英文報告)
講評老師: 楊倍昌

Full Text:

CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation
Kavya Rakhra, Pavan Bachireddy, Tahera Zabuawala, Robert Zeiser, Liwen Xu, Andrew Kopelman, Alice C. Fan, Qiwei Yang, Lior Braunstein, Erika Crosby, Sandra Ryeom and Dean W. Felsher
Cancer Cell 18, 485–498, 2010
Speaker: Weng, Tzu-Yang
Commentator: Prof. Yang, Bei-Chang
Place: Room 602
Time: 03-25, 16:00-16:50
Background: Previous studies show that oncogene addiction is related to cell autonomous process. Host immune system also plays an important role in tumorigenesis.
Objective: However, their functions in tumor regression upon oncogene inactivation are not well understood.
Results: In this study, authors used several types of immune-deficient transgenic mice such as SCID, RAG2-/- and CD4-/- mice, and conditional oncogene inactivated mice to explore the tumor regression after MYC and BCR-ABL oncogene inactivation. They found that absence of an intact immune resulted in tumor recurrence, and failed to enhance cellular senescence or inhibited angiogenesis upon oncogene inactivation. Furthermore, expression of thrombospondin in CD4+ T cells was also essential to induce sustained tumor regression in those mouse models.
Conclusion: Overall, authors showed that CD4+ T cells were important to remodel tumor microenvironment and result in tumor regression through cytokine or chemokine expression upon oncogene inactivation.
Paradoxical roles of the immune system during cancer development, Nature Reviews Cancer 6, 24-37, 2006