Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens (Nat Neurosci, 2010, 13:1137-1143)

報告日期: 2010/12/17
報告時間: 16:20/17:10
報告學生: 周迪侖
講評老師: 游一龍
附件下載:

Full Text: http://basicmed.med.ncku.edu.tw/admin/up_img/991217-2.pdf

Dnmt3a regulates emotional behavior and spine plasticity
in the nucleus accumbens
 
Quincey LaPlant, Vincent Vialou, Herbert E Covington III, Dani Dumitriu, Jian Feng, Brandon L Warren, Ian Maze, David M Dietz, Emily L Watts, Sergio D Iñiguez, Ja Wook Koo, Ezekiell Mouzon, William Renthal, Fiona Hollis, Hui Wang, Michele A Noonan, Yanhua Ren, Amelia J Eisch, Carlos A Bolaños, Mohamed Kabbaj, Guanghua Xiao, Rachael L Neve, Yasmin L Hurd, Ronald S Oosting, Gouping Fan, John H Morrison& Eric J Nestler
Nature Neuroscience (2010) 13:1137-1143.
 
Speaker: Dylan Cho
Commentator: Lung Yu, PhD
Date: December 17, 2010
Place: Room 602
 
DNA methyltrnsferases (Dnmt3a and Dnmt3b) abundantly express in the central nervous system, including nucleus accumbens (NAc) (1). It regulates DNA methylation and further alters gene expression (2). In addition, gene expression in the NAc is regulated by chronic cocaine use and chronic social defeat stress (2, 3). However, it is still unclear whether the regulation of DNA methylation response to these two distinct emotional stimuli. The results of this paper indicate that Dnmt3a expression in the NAc was regulated by chronic cocaine use and chronic social defeat stress. Moreover, manipulation to inhibit DNA methylation in the NAc heightens cocaine reward and dampens depression-like behavior. Nevertheless, overexpression of Dnmt3a in the NAc attenuates cocaine reward and potentiates depression-like behavior. Furthermore, this paper also reveals that Dnmt3a in the NAc is necessary and sufficient to mediate chronic cocaine use-induced spinogenesis, which was occurred selectively in thin spines. In conclusion, these results suggest that Dnmt3a in the NAc play an important role in regulation of emotional behavior and spine plasticity when face to emotional stimuli.
 
References:
1. Feng, J., et al. (2005) Dynamic expression of de novo DNA methyltransferase Dnmt3a and Dnmt3b in the central nervous system. J. Neurosci. Res. 79:734-746.
2. Tsankova, N., et al. (2007) Epigenetic regulation in psychiatric disorders. Nat. Rev. Neurosci. 8:355-367.
3. Kumar, A., et al. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314.