Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes (Cell 2019, 178:795–806)

報告日期: 2019/10/08
報告時間: 15:10/16:00
報告學生: 鄭政軒
講評老師: 阮振維
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Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Erick Riquelme, ……., Florencia McAllister, Cell 178, 795–806 August 8, 2019

Speaker: Cheng-Hsuan Cheng (鄭政軒)               Time: 15:10~16:00, Oct. 8th, 2019

Commentator: Dr. Jhen-Wei Ruan (阮振維老師)   Place: Room 602

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a disease with poor prognosis1. Most patients present with advanced stage disease with a five-year overall survival of 9%2. But a minor subset of patients survives more than five years after surgery3. Andthe main determinants of such long-term survival (LTS) remain largely unknown. Here, the authors aim to clarify the role of tumor microbiome in affecting LTS. They utilized 16s rRNA sequencing to analyze tumor microbiota from two geographically disparate PDAC cohorts which were initially separated into short-term survival (STS) and LTS. Firstly, from the microbiota composition analysis, the tumor microbial diversity was significantly higher in LTS patients than in STS patients in both cohorts. On the other hand, the intratumoral bacteria were also found to drive antitumor immune responses through T cell recruitment and activation. Next, human-to-mouse fecal microbiota transplantation (FMT) was performed to assess the effect of microbiome modulation on tumor growth and the capacity of gut microbiome to shape tumor microbiome. Overall, this study unravels the role of tumor microbiome in prolonged survival in PDAC and elucidates that intratumoral microbiome composition, which is influenced by gut–tumor microbial crosstalk, shapes the host immune responses and natural history of disease.

References

1   Hidalgo, M. Pancreatic Cancer. New England Journal of Medicine 362, 1605-1617, doi:10.1056/NEJMra0901557 (2010).

2   Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2018. CA: A Cancer Journal for Clinicians 68, 7-30, doi:10.3322/caac.21442 (2018).

3   Dal Molin, M. et al. Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis. Clinical Cancer Research 21, 1944-1950, doi:10.1158/1078-0432.Ccr-14-2600 (2015).