Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation(Cell 2018, 175:1561–1574)

報告日期: 2019/04/26
報告時間: 17:10/18:00
報告學生: 郭宜盈
講評老師: 陳柏熹

Secretin-activated brown fat mediates prandial thermogenesis to induce satiation

Li et al., Cell 2018; 175,1561-1574

Speaker: Yi-Ying Kuo (郭宜盈)

Commentator: Dr. Po-See Chen (陳柏熹老師)

Time and Date: 17:10-18:00, April 26, 2019

In general, thermogenesis in brown adipose tissue (BAT), as known as non-shivering thermogenesis, majorly responses to cold exposure by the norepinephrine-activated pathway. Besides, BAT also involves in meal-associated thermogenesis. The function and underlying mechanism of meal-associated BAT thermogenesis remain unclear. Moreover, several gut hormones have correlated with meal-associated thermogenesis and food controlling. Hence, the authors hypothesized that gut hormones might activate BAT-dependent thermogenesis and the central perception of satiation after meals. They first identified that the secretin receptors are highly expressed in BAT. Thus they postulated that secretin is the key hormone to regulate meal-associated BAT thermogenesis. Next, secretin can activate BAT thermogenesis by canonical cAMP-PKA pathway. Importantly, meal-increased BAT temperature and satiation were abolished using secretin antibodies to neutralize the endogenous secretin activity, demonstrating that secretin could directly induce satiation through activating BAT thermogenesis. Collectively, this study highlighted the function of BAT in the control of satiation.

Take-home message: Secretin stimulates brown adipose thermogenesis and control satiation.

Keywords:Secretin, meal-associated thermogenesis, brown adipose, satiation