Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior (Molecular Psychiatry 2014, 19:1078-1084)

報告日期: 2015/05/22
報告時間: 15:10/16:00
報告學生: 鍾宜倫
講評老師: 郭余民
附件下載: 下載[1494-1425859658-1.pdf] 

Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior

Molecular Psychiatry (2014) 19, 1078–1084

Speaker: Chung Yi-Lun (鍾宜倫)          Location: Room 602

Commentator: Yu-Min Kuo, Ph.D.         Time: 2015/05/22, 15:10~16:00

Obesity is a major public health problem and a serious global epidemic.1It believed to have been driven by food environment that promotes consumption of inexpensive, convenient, high calorie, palatable foods. The increasing number of obese in the US adds urgency to the efforts to understand the mechanisms underlying pathological overeating. Dopamine (DA) is a neurotransmitter known to play a major role in motivation that is involved with reward and prediction of reward.2 DA neurocircuitry may contribute to opportunistic eating and obesity also development habit formation. However, to understanding of the role of the dopamine system in the motivation for food intake will help the development of better therapeutic interventions. We measured striatal dopamine D2-like receptor binding potential (D2BP) using positron emission tomography in 43 human subjects with body mass indices (BMI) ranging from 18 to 45 kgm−2. These results suggest that opportunistic eating behavior and BMI were both positively associated with D2BP in the dorsal and lateral striatum. But BMI was negatively associated with D2BP in the ventromedial striatum. The obese people have alterations in dopamine neurocircuitry that may increase their susceptibility to opportunistic overeating while at the same time making food intake less rewarding, less goal directed and more habitual.

References   

  1. Zhang Y, Liu J, Yao J, et al. Obesity: pathophysiology and intervention. Nutrients 2014 Nov;6(11):5153-5183.
  2. Wickens JR, Horvitz JC, Costa RM, Killcross S. Dopaminergic mechanisms in actions and habits. The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Aug 1;27(31):8181-8183.