Diverse intracellular pathogens activate type III interferon expression from peroxisomes (Nature immunology 2014 ; 15:717–726)

報告日期: 2014/10/07
報告時間: 5:10/6:00
報告學生: 賴彥仲
講評老師: 凌斌
附件下載: 下載[1428-1412163957-1.pdf] 

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

Charlotte Odendall, Evelyn Dixit, Fabrizia Stavru, Helene Bierne, Kate M Franz, Ann Fiegen Durbin, Steeve Boulant, Lee Gehrke, Pascale Cossart & Jonathan C Kagan.

Nature Immunology 15,717–726 (2014) doi:10.1038/ni.2915

Speaker: Yen-Chung Lai (賴彥仲)             Time: 17:10 ~ 18:00 am, October 7, 2014

Commentator: Dr.Ling, P (凌斌老師)        Place: 醫學院 601

 

Abstract:

        Despite type I interferon response is considered the classic strategy to act as an antiviral response in mammals, recently type III interferon is found to have important roles in diverse antiviral immune responses1, 2.  However, the molecular mechanism of how this type I interferon-independent pathway is activated is still unclear. In this study, the authors identified a type III interferon-activation pathway which was induced from peroxisome. They found that, on peroxisomal organelle, RIG-I like receptor (RLR) signaling via adaptor protein MAVS did not induce type I interferon expression but this RLR-MAVS signaling pathway was at the upstream to drive type III interferon response. In addition, some transcription factors such as IFR3 and IFR1 were required independently at the downstream for type III interferon expression. They also found that type III interferon expression was critical in polarization of particular epithelial cells such as intestine, liver and lung. Corresponding to this aspect, patients who had defective peroxisome often suffered from developmental abnormalities and diverse intracellular pathogen infections. Taken together, the authors revealed the importance of peroxisome in regulating type III interferon expression and provided insights between peroxisome disorder and human disease.

 

References:

  1.  Noyce, R.S., Collins, S.E. & Mossman, K.L. Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. J. Virol. 80, 226–235 (2006).
  2. Richard Sutejo, et al.:Activation of type I and III interferon signaling pathways occurs in lung epithelial cells infected with low pathogenic avian influenza viruses.PLoS One.;7(3):e33732 (2012)