Corticostriatal plasticity is necessasy for learning intentional neuoprosthetic skills. ( Nature. ; 483(7389): 331–335. doi:10.1038/nature10845)

報告日期: 2014/11/25
報告時間: 5:10/6:00
報告學生: 葉玟秀
講評老師: 郭余民
附件下載: 下載[1445-1412238370-1.pdf]  下載[1445-1412238370-2.pdf] 

Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills

Aaron C. Koralek1,*, Xin Jin5,*, John D. Long II1, Rui M. Costa5,6,ψ, and Jose M.Carmena1,2,3,4,ψ

Nature. ; 483(7389): 331–335.

SpeakerWen-HsiuYeh (葉玟秀)             Date2014.11.25 /17:10~18:00

CommentatorYu-Min Kuo, Ph.D.(郭余民 老師)         PlaceRoom 602

The learning of physical and abstract skills have been implicated from the motor cortex (M1), and the striatum can implicate the physical skill. It is still unclear if the striatum is required for the learning of abstract skills and how the corticostriatal circuit undergoes plasticity during the learning. This study utilized the intentional neuroprothetic  paradigm throughout the electrophysiological analysis combined with genetic manipulations to investigate corticostriatal plasticity in rodents. First, the authors found that rodents learned operantly control in response to their M1 activity even when sensory and motor nerve ending around whisker was inactivated by lidocaine. Second, the action-outcome manipulations, devaluation and omission tests have indicated intentional and goal-directed purpose to carry out task rather than habitual. Next, the intentional learning process exhibited the greatest firing rate in dorsal striatum (DS) neurons in late period. Moreover, both M1and the DS neuronal activities were pronounced correlation and strong coherence within 4-8 Hz. Finally, knockouting the N-Methyl-D-aspartic acid (NMDA) receptors of striatum neurons have impaired corticostriatal long-term potentiation and led to no learning improvement. Collectively,the striatum is important for learning and selecting abstract actions, and the corticostriatal network exhibits profound plasticity during the intentional learning.

Reference:

David Badre, Andrew S. Kayser, and Mark D’Esposito. Frontal cortex and the  

discovery of abstract action rules.Neuron . 2010 April 29; 66(2): 315–326.

doi:10.1016/j.neuron.2010.03.025.