Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. (Nat Commun. 2015 Jan 23;6:5988.)

報告日期: 2015/03/20
報告時間: 15:10/16:00
報告學生: 黃光靖(以英文報告)
講評老師: 陳毓宏
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Gd-metallofullerenol nanomaterial as non-toxic breast

cancer stem cell-specific inhibitor

Speaker: Kuang-Jing Huang                                      Date: 2015/03/20

Commentator: Prof. Yu-Hung Chen                            Room: 602

Abstract:

     During the past decade, nanopatrticles and their surface modification have demonstrated great potential in cancer therapy and diagnosis. Gd-metallofullerenol nanomaterial (Gd@C82(OH)22) originally was used in cancer diagnosis. Authors previous already discovered this Gd-metallofullerenol nanomaterial is low cyto- and systemic-toxicity despite a remarkable anticancer capacity in a many kinds of solid cancers. However, the mechanisms by which Gd-metallofullerenol nanoparticles mediate this cancer target specificity remain undefined. In recent reported, tumor microenvironment is the major hurdles to successful treatment of cancer. Tumor cells can secret TGF-b to domesticate sounding anti-cancer stromal cells. These stromal cells finally become pro-cancer fate cells and incubate a suitable environment to promote cancer growth andimmunosuppression for further epithelial–mesenchymal transition (EMT), angiogenesis and metastasis. In the result, Gd@C82(OH)22 nanoparticles reverse cancer cells morphology from mesenchymal to epithelial phenotype and inhibit cancer metastasis, EMT, angiogenesis and cancer tem sells formation. Additional TGF-b and HIF-a can rescue this inhibition efficacy of Gd@C82(OH)22 nanoparticles. Combined with previous their studies, this Gd@C82(OH)22 nanoparticles accomplished all-in-one cocktail cancer therapy and structure biology maybe is a next research hotspot in exploring the interaction mechanism of nanomaterials and their target biomarkers.

References:

  1. Y. Liu et al., Nat Commun 6, (2015).