Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory. (Nat Neurosci. 2011 May; 14(5):656-61)

報告日期: 2015/12/08
報告時間: 5:10/6:00
報告學生: 葉玟秀(英文報告)
講評老師: 謝淑蘭
附件下載: 下載[1529-1443056045-1.pdf] 

Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory

Theodore P Zanto, Michael T Rubens, Arul Thangavel & Adam Gazzaley

SpeakerWen-Hsiu Yeh (葉玟秀)           Date2015.12.08 /17:10~18:00

CommentatorShu-Lan Hsieh, Ph.D. (謝淑蘭 老師)        PlaceRoom 602

Selective attention describes goal-directed behavior achieved by orienting the focus of conscious awareness toward relevant stimuli and away from irrelevant or competing stimuli. Working memory is the cognitive operation that underlies our ability to temporarily maintain and manipulate attended information in mind when it is no longer accessible in the environment to guide behavior. The prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Therefore, the methods of this study using the functional magnetic resonance imaging (fMRI) to guide repetitive transcranial magnetic stimulation (r-TMS) with electroencephalographic (EEG) recordings in humans , they perturbed PFC function at the inferior frontal junction (IFJ) in participants before they performed a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. This study data further suggests that broad alpha-band (7–14 Hz) phase coherence subserved this long-distance top-down modulation. Thus, this study conclude that early top-down activity modulation during stimulus processing driven by attentional demands is causally related to subsequent working memory performance.

Reference:

Theodore P. Zanto , Michael T. Rubens, Jacob Bollinger, Adam Gazzaley. Top-down modulation of visual feature processing: The role of the inferior frontal junction. NeuroImage 53 (2010) 736–745

Teven A. Hillyard and Lourdes Anllo-Vento.Event-related brain potentials in the study of visual selective attention. Proc. Natl. Acad. Sci. USA Vol. 95, pp. 781–787, February 1998