Hypothalamic neuronal circuits regulating hunger-induced taste modification (Nature Communications 2019, 10:4560 )

報告日期: 2020/05/08
報告時間: 17:10/18:00
報告學生: 郭宜盈(英文報告)
講評老師: 游一龍
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Hypothalamic neuronal circuits regulating hunger-induced taste modification

Fu et al., 2019, Nature communication 10: 4560

Speaker: Yi-Ying Kuo (郭宜盈)

Commentator: Prof. Lung Yu (游一龍老師)

Time and Date: 17:10-18:00, May 8, 2020

Taste preference and sensitivity, showcasing a critical function of gustatory perception in regulating feeding behavior, are manipulated by various factors, especially hunger drives. Interestingly, one line of evidence indicates that starvation induces increases in the sweet taste preference, while decreases in the sensitivity of bitter taste using a Drosophila model [1]. To investigate the neuronal circuits regulating hunger-induced taste modification, these authors have used chemogenetic and optogenetic approaches to tackle the related hypothesis. First, they observed that fasted mice exhibited an increased sweet taste preference but decreased bitter taste sensitivity. This hunger-induced taste modification was produced by specific activation of agouti-related peptide neurons in arcuate nucleus. Glutamatergic neurons in lateral hypothalamus send the efferent fibers to regulate taste preference. Moreover, the glutamatergic projections from lateral hypothalamus to lateral septum and lateral habenula controlled the sweet and bitter taste alterations, respectively. Collectively, this study suggests that the neuronal circuits as enlisted above are especially relevant to the taste perception alteration in response to starvation condition.

Keywords: Agouti-related peptide, hunger-induced taste modification, hypothalamus, arcuate nucleus

Reference:

  1. Inagaki, H.K., K.M. Panse, and D.J. Anderson, Independent, reciprocal neuromodulatory control of sweet and bitter taste sensitivity during starvation in Drosophila. Neuron, 2014. 84(4): p. 806-20.