Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid (Nature. 2019, 572(7767):62-66.)

報告日期: 2019/11/29
報告時間: 15:10/16:00
報告學生: Mee-Inta Onanong
講評老師: 劉秉彥

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Ji Hoon Ahn, Hyunsoo Cho, Jun-Hee Kim, Shin Heun Kim, Je-Seok Ham, Intae Park, et al.

Nature, 2019

Speaker: Onanong Mee-inta                                 Date/Time: 15.10-16.00, Nov. 29, 2019

Commentator: Prof. Ping-Yen Liu                          Place: room 602


       Meningeal lymphatic vessels (mLVs) are found in recently years that function in the cerebrospinal fluid (CSF) and interstitial fluid (ISF) clearance into the cervical lymph nodes (1). Most of previous studies focused on the mLVs in the dorsal part of the skull, but the exact pathway of CSF drainage has remained unclear (2, 3). In this research, the mLVs, especially in the basal part of the skull, were revealed in terms of the specialized morphological features, anatomical location and functions. The morphology of basal mLVs showed the discontinuously sealed loose button-like junctional pattern of lymphatic endothelial cells and protruding capillary branches with lymphatic valves, which can facilitate the CSF uptake and drainage. Moreover, these vessels located adjacent to the subarachnoid space. For the functional assessment by using CSF contrast-enhanced magnetic resonance imaging and fluorescent imaging, this demonstrated that basal mLVs were the main routes for the clearance of CSF macromolecules. Interestingly, the character of basal mLVs and CSF drainage were changed with age. Altogether, these findings provide more understanding details about the importance of mLVs, including the effects of aging to the mLVs impairment.


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  3. Antila, S. et al. Development and plasticity of meningeal lymphatic vessels. J. Exp. Med. 214, 3645–3667 (2017).