Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs. (Cell 2016, 166(2):299-313)

報告日期: 2016/12/02
報告時間: 4:00/4:50
報告學生: 陳羿帆
講評老師: 黃阿敏
附件下載: 下載[1582-1473666848-1.pdf] 

Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.

Orefice LLZimmerman ALChirila AMSleboda SJHead JPGinty DD.

2016 Jul 14;166(2):299-313.

Speaker: 陳羿帆                 Time: 16:00-16:50, December 2nd, 2016

Commentator: 黃阿敏老師         Place: Room 602

Autism spectrum disorders (ASDs), a group of neurodevelopmental disorders characterized with abnormal social communication and interaction. Patients with ASDs also experience aberrant tactile sensitivity, vibration and thermal pain. However, the underlying neural mechanisms of abnormal tactile sensitivity remain unclear. In this study, the authors hypothesized that touch perception deficits in ASDs lead to aberrant cognitive and social behaviors. First, the mice mutant for the autism-associated genes Mecp2, Shank3 and Fmr1 were shown to alter tactile discrimination and enhance innocuous touch sensation. Somatosensory neurons deletion of Mecp2 or Gabrb3 gene induced mechanosensory hyperactivity through loss of GABAA receptor-mediated presynaptic inhibition in spinal cord dorsal horn. Moreover,mice lacking Mecp2 or Gabrb3 selectively in peripheral sensory neurons exhibited social, tactile deficits and anxiety-like behaviors during development, but not in adulthood. Furthermore, restoring Mecp2 expression in the somatosensory neurons in a Mecp2-null micerescued the touch perception dysfunction, social deficits and anxiety-like behaviors. Taken together, these results indicate that impairments in somatosensory nerve system during development time window contribute to abnormal social interaction and anxiety-like behaviors in ASD mouse models.

Reference:

1.     DeLorey TM, et al. (2008) Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav. Brain. Res. 187(2):207-20.

2.     Silverman JL, et al. (2010) Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11(7):490-502.

 

  1. DeLorey TM, et al. (2008) Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder. Behav. Brain. Res. 187(2):207-20.
  2. Silverman JL, et al. (2010) Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11(7):490-502.