CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages. ( Cancer Research, 2016 76(9):2552-60)

報告日期: 2016/12/02
報告時間: 5:10/6:00
報告學生: 袁俊文
講評老師: 簡伯武
附件下載: 下載[1583-1473667255-1.pdf] 

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

Ishani De, Megan D. Steffen, Paul A. Clark, Clayton J. Patros, Emily Sokn,Stephanie M. Bishop, Suzanne Litscher, Vilena I. Maklakova, John S. Kuo, Fausto J. Rodriguez3, and Lara S. Collier

Cancer Res. 2016 May 1;76(9):2552-60

Speaker: Chun-Man Yuen                                                  Time: 17:10~18:00, 12/02 Commentator: Prof. Gean, Po-Wu/Alice Y.W. Chang           Place: Room 602

Abstract:

  High-grade glioma (i.e. glioblastoma multiforme, GBM) is currently still a poor prognosis tumor after aggressive treatments therefore other means of treatment is emergent needed. The dynamic of glioma microenvironment is interested as lots of interaction there is probably related to the progression of tumor. Tumor-associated macrophages (GAMs) is believed to play a key role in the tumor stroma, tumor angiogenesis, proliferation and invasion. 1 Colony-stimulating-factor-1 (CSF1) may promote microglia/macrophage activation and alter polarization, therefor inhibition of CSF1 signaling is believed as a strategy of tumor control . 2, 3 Current research on glioma always use a orthotopic xenograft/allograft model which may elicit immune response and de novo gliomagenesis in vivo in an intact immune environment may be more close to clinical scenario. This article study the dynamic of CSF1 on macrophage/microglia during gliomagenesis in an autochthonous glioma model.

References:

  1. Zhang H, Zhang W, Sun X, Dang R, Zhou R, Bai H, et al: Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization. Oncotarget, 2016
  2. Hume DA, MacDonald KP: Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 119:1810-1820, 2012
  3. Chitu V, Stanley ER: Colony-stimulating factor-1 in immunity and inflammation. Curr Opin Immunol 18:39-48, 2006