Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation (mBio 2016, 7(6):e01965-16)

報告日期: 2017/03/21
報告時間: 3:10/4:00
報告學生: 陳宏銘
講評老師: 黃一修
附件下載: 下載[1618-1487727797-1.pdf] 

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation

Christopher S, Colleen R. K, Lawrence J. B, et al.

MBio. 2016 Dec 20;7(6). pii: e01965-16.

Speaker: Hong-Ming Chen         Date: 2017/03/21, 15:10-16:00

Commentator: I-Hsiu Huang     Location: Room 602

Abstract

 

Clostridium difficile infection is a worldwide emerging infectious disease attributed by some hypervirulent C. difficile strains with greater resistance to antibiotics and increased toxin production. Recurrence of C. difficile infection (rCDI) occurs in approximately 25% of successfully treated patients resulting either from a consequence of resident spores or infection from local environmental contamination. Recurrence of disease is frustrating because there is no approved treatment alternative that provides a lower probability of yet another recurrence. Fecal Microbiota Transplantation (FMT) is a new treatment that has been shown to be over 90% effective for treating C. difficile infection in patients who had previously failed to recover with antibiotic therapy. Interestedly, the previously studies have found that the treatment of heterologous FMT (H-FMT) treatment was better than the autologous FMT (A-FMT). However, in some cohort study, nearly all the patients recovered following A-FMT. Here, the authors hypothesized that unique taxa would be present in fecal samples from subjects cured by A-FMT that were absent from those who relapsed. Using Illumina NGS, they find that the gut bacteria communities of H-FMT subjects similar to that from donors with high relative abundances of genera within Bacteroidetes and Firmicutes, and this composition were significantly different in A-FMT subjects. Importantly, the authors found that subjects cured by A-FMT had greater abundances of the Clostridium XIVa clade and Holdemania bacteria before the treatment which increased in H-FMT. Taken together, the authors suggested that the treatment of rCDI following cessation of antibiotic therapy may not necessary to transplant complete microbiota if functionally critical taxa are present.

 

Reference

 

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