Enhanced virulence of influenza A virus with the haemagglutinin of the 1918 pandemic virus (Nature, 431:703-707, 7 October 2004)

報告日期: 2005/09/20
報告時間: 15:10/16:00
報告學生: 孫宏羽
講評老師: 王貞仁
附件下載:

Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus

Darwyn K. et al.   Nature (2004), 431:703-707

Commentator王貞仁 老師                                                 Speaker孫宏羽

Time15:10-16:00                                                         Place602 Room

20 Sep. 2005

Abstract:

While the whole world was under the threat of World War I, the deadly intimidation was lurking in the shadows. In late August of 1918, a virulence strain of Influenza virus emerged and swept the globe in 6 month, killing more than 20 million people. The fragments of RNA of 1918 Influenza virus were isolated from the preserved lung tissue of a victim of the deadly fall wave of the pandemic1. Haemagglutinin (HA) and neuraminidase (NA) are the two major viral surface glycoprotein of Influenza virus and are responsible for host immune resonance, host range and enhance the virulence of infection. The phylogenetic analysis of HA2 and NA3 gene of 1918 strain revealed the  strain might be evolved from avian strain in previous study. Herein, the authors demonstrate the HA gene of 1918 strain enhance the virus virulence. The Influenza virus strain containing 1918 viral HA causes massive recruitment of polymorphonuclear cells and severe haemorrhage. Furthermore, the HA viral protein of 1918 strain preferentially binds to human receptor and the populations born after 1934 had only limited neutralizing activity against the Influenza virus strain expressing 1918 HA. HA gene of 1918 strain might still circulate in avian pool and could cause another outbreak of influenza pandemic.

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