Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit. Cell 2016, 165(6):1347-1360.

報告日期: 2017/10/27
報告時間: 17:10/18:00
報告學生: 謝宗祺
講評老師: 莊季瑛
附件下載: 下載[1686-1506047509-1.pdf] 

Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit

Liu et al., 2016, Cell 165, 1347–1360

Speaker: Hsieh, Tsung-Chi                                     Date: 2017/10/27

Commentator: Prof. Chuang, Jih-Ing                       Location: Room 602

Sleep is an archetypal motivated behavior which is regulated by homeostatic drive. Previous studies indicate that sleep drive (sleep pressure) will be enhanced by prolonged wakefulness and causing increased sleep amount and/ or depth (sleep rebound)(Borbély, 1982). However, the mechanisms underlying the generation and the perdurance of such homeostatic drive are still unclear. The authors carried out a large-scale neuronal driver screen in Drosophila and identified R2 neurons, a subset of ellipsoid body (EB) neurons. The activation of R2 neurons generates sleep drive, and besides, through patch-clamp analysis, the data indicates that the activity and excitability of R2 neurons are enhanced following sleep loss. Furthermore, functional images reveal that intracellular Ca2+ levels and the synaptic strength of R2 neurons are associated to the level of homeostatic sleep drive and are capable of manipulating it. Last of all, translational profiling experiments show that NMDA receptors in R2 neurons are upregulated following sleep deprivation reflecting the “sleep-need’’-dependent plastic changes, and the NMDA receptors signaling in R2 neurons is required for generating sleep drive. These studies suggest a model that there is a dedicated homeostatic integrator circuit which encodes sleep pressure by plastic changes, also revealing the potential mechanisms for the generation and persistence of homeostatic sleep drive.

Reference:

Borbély, A.A. (1982). A two process model of sleep regulation. Hum. Neurobiol.1,

195–204.