Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen (J Exp Med, 2005, 202:1375-1386)

報告日期: 2006/04/18
報告時間: 17:10/18:00
報告學生: 萬書彣 (英文報告)
講評老師: 黎煥耀
附件下載:

 

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

 

Speaker: 萬書彣

Commentator: 黎煥耀 老師

Time: 17:10-18:00 4/18/2006

Place: Room 602

 

Abstract

 The authors developed a monoclonal, antigen-specific model in which naïve antigen-specific CD4+ T cells were transferred into lymphopenic mice that express an endogenous antigen (Ag) as a systemic, secreted protein1. This model was analogous to graft-versus-host disease (GvHD) which means transplanted T cells react against alloantigens from recipients2. In these lymphopenic Ag-expressing mice, the Ag-recognizing T cells expanded and differentiated into effector cells causing severe pathologic effects in the first 2 weeks. Within 2-3 weeks, the surviving mice began to recover and this was due to the generation of FoxP3+CD25+ regulatory T cells in the periphery. IL-2 is known to both stimulate and terminate T cell response3. The absence of IL-2 led to miner severe phenomenon in the beginning, but it led to a failure to recover from disease at the end. Results demonstrated that IL-2 play a dual role in the generation of T cells. In the absence of IL-2, the reduction of effector T cells lightened the disease at first, however, the lack of regulatory T cells made the disease more severe in the late phase. Thus, IL-2 influences this antigen-specific T cell population to different fates of development, and this might occur sequentially or in parallel.

 

References:

1.     Brigit, K., et al. (2005). Sequential development of interleukin 2-depedent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202, 1375-1386.

2.     Ferrara, J. L. and Deeg, H. J. (1991). Graft-versus-host-disease. N. Engl. J. Med. 324, 667-674.

3.     Gaffen, S. L. and Liu, K. D. (2004). Overview of interleukin-2 function, production and clinical applications. Cytokine. 28, 109-123.