Structural basis of potent Zika-dengue virus antibody cross-neutralization. Nature 2016, 536(7614): p. 48-53.

報告日期: 2017/10/31
報告時間: 16:00/16:50
報告學生: 邱彥綺
講評老師: 王淑鶯
附件下載:

Evolutionary enhancement of Zika virus infectivity

in Aedes aegypti mosquitoes

Liu, Y., et al., Nature, 2017. 545(7655): p. 482-486.

Speaker: Yen-Chi Chiu (邱彥綺)                                  Time: 16:00-17:00, Oct. 31, 2017

Commentator: Prof. Yee-Shin Lin                               Venue: 602

Abstract

The Zika virus (ZIKV) epidemic is an emergency in the past decade. ZIKV is a member of the Flaviviridae family, and transmitted by the infected mosquitoes as the other arbovirus. From the first discovered of rhesus monkey in 1947 in Uganda (Africa) to present, all 41 known strains of ZIKV have been identified and classified to African and Asian lineage by sequence analysis. Nevertheless, the recent ZIKV epidemic has been traced to the Asian clade, including the massive outbreaks in the Pacific in 2007 and in the Americas (Brazil) in 2015. Even though the large studies of flaviviruses such as dengue virus, West Nile virus, and Japanese encephalitis virus, the pathogenesis of ZIKV infection still remains poorly understood. In this study, Liu et al. reported that an amino acid substitution is associated with increased infectivity of the ZIKV strain, and it’s responsible for the epidemic in the Americas in the mosquito vector A. aegypti. The results demonstrated significantly higher infectivity in GZ01 strain (KU820898 China 2016, traveler from Venezuela) than in a FSS13025 strain (KU955593 Combodia 2010) in the A. aegypti vector. The increased infectivity of ZIKV in A. aegypti was linked to the secretability of nonstructural protein 1 (NS1). The critical point was evidenced that the amino acid was substituted from alanine to valine at residue 188 in NS1. The data show that the point mutation at A188V substitution in FSS13025 strain cause substantially increased the secretion of NS1 and its infectivity in A. aegypti. However, there are still needs more evidences to reveal the opportunity and process in this evolution.

References

1. Liu, J., et al., Nat Microbiol, 2016. 1(9): p. 16087.

2. Han, G.Z., Trends Microbiol, 2017. 25(8): p. 603-605.