Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion (Cell, 121:335-348, 6 May 2005)

報告日期: 2005/10/14
報告時間: 15:10/16:00
報告學生: 吳明恒
講評老師: 張 玲

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion


Cell, Vol. 121, 335–348, May 6, 2005

Speaker: Ming-Heng Wu                                     Time: 2005/10/14

Commentator:  Ling chang                                   place: Room 602


    Stromal-epithelial interactions play a critical role in cancer progression. Canconoma-associated fibroblasts (CAFs), which are also termed activated fibroblasts or myofibroblasts have been found in the stroma around invasive human breast cancers. Previous studies also showed that stromal fibroblasts explanted from human prostate carcinoma can assist tumor formation. However, the mechanisms of how myofibroblasts contribute tumor growth and progression are unclear. By using human tumor xenograft model, the authors observed that primary fibroblasts from invasive human breast carcinoma can promote tumor growth and angiogenesis. They sought to elucidate the underlying mechanisms by DNA microarry expression analysis. Gene-expression profiles of CAFs are different from normal or counterpart fibroblasts. The analysis showed that an elevation of stromal cell-derived factor-1 (SDF-1) expression in CAFs. SDF-1 released from CAFs contributes to the recruitment of circulating endothelial progenitor cells (EPCs) into tumors through its receptor CXCR4 which can enhance tumor angiogenesis and growth. Besides, it can also induce cancer cell proliferation and contribute tumor growth. In conclusion, SDF-1 secreted from CAFs can promote cancer progression through endocrine and paracrine stimulations.


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