Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling (Cancer Cell, 8:13-23, July 2005)

報告日期: 2005/10/14
報告時間: 16:00/16:50
報告學生: 黃議賢
講評老師: 湯銘哲
附件下載:

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

Cancer cell, Vol. 8, 13-23 (2005)

 

Time: Oct. 14. 2005, 16:00-16:50

Place: Room 602

Speaker: 黃議賢

Commentator: 湯銘哲 老師

Abstract:

Angiogenesis plays an important role during embryogenesis, adult vascular remodeling and in several pathological disorders, as in tumor development.  These processes controlled by several angiogenic factors, including growth factor, cytokines, and extra-cellular matrix.  Angiogenesis is essential for the primary and metastatic growth tumor.  Recently, many studies had show that tumor cells can secrete angiogenic factors such as IL-8, or VEGF and other growth factors to induce angiogenesis, then promote tumor growth.  In 1971, Folkman proposed that anti-angiogenesis might be an effective anticancer strategy.  Until now, many strategies designed for human cancer therapy through block angiogenic factors for example VEGF, but it has not been successful in many tumor types, suggesting that other factors or competent may also play a critical role in tumor angiogenesis.  In this study, the authors using microarray and matrigel model system to find out a novel mechanism of tumor associated angiogenesis.  Tumor–associated growth factors, that induce the expression of Jagged 1 in head and neck squamous cell carcinoma (HNSCC) through by activating MAPK signaling pathway.  The Jagged 1 expressing in SCC cells directly interact with Notch receptor on endothelial cells, can regulated EC differentiation and promoted angiogenesis to support tumor growth .  In addition, the expression level of Jagged 1 correlated with the development of HNSCC.  These observations suggest a novel mechanism by which tumor cell can trigger angiogenesis through direct interact with EC via Jagged 1-Notch signaling. 

 

References:

1.         Zeng Q, Li S, Chepeha DB, Giordano TJ, Li J, Zhang H, Polverini PJ, Nor J, Kitajewski J, Wang CY.  Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.  Cancer Cell. 2005 Jul; 8(1):13-23.

2.         Iso T, Hamamori Y, Kedes L.  Notch signaling in vascular development.  Arterioscler Thromb Vasc Biol. 2003 Apr 1; 23(4):543-53. Epub 2003 Feb 13.