A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex (Neuron 2019, 102:668–682)

報告日期: 2019/11/15
報告時間: 16:00/16:50
報告學生: 孫莉涵
講評老師: 許桂森
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A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex

Neuron, May 8, 2019

Speaker: Li-Han Sun

Commentator: Kuei-Sen Hsu Ph.D.

Time and Date: 16:00-16:50, November 15, 2019

Fear is an emotional response to some events that can help people to avoid danger. Prefrontal cortex (PFC) is one of important region in brain that control fear response. However, the underlying mechanism is still unclear, especially the function of inhibitory interneurons (INs) in PFC, such as parvalbumin (PV) INs. First, the authors established a social fear conditioning (SFC) paradigm to induce social fear in mice. Second, they used this paradigm to demonstrate that dorsal medial PFC (dmPFC) showed hyperactivity in social fear. Moreover, pretreatment with GABAa receptor agonist muscimol (MUS) could eliminate it. Third, the authors established chronic electrophysiological recordings to explore the dmPFC microcircuitry underlying social fear. They found the hyperactivity in pyramidal neurons and hypoactivity in PV INs. Next, they used chemogenetics to inactivate CaMKII positive neurons and activate PV INs to reduce social fear expression directly. Interestly, the other subtype of INs in mouse neocortex, somatostain (SST), is increased in social fear. Finally, they also used chemogenetics to inactivate SST INs to find they can alleviate social fear. Taken together, the authors found a disinhibitory microcircuit about social fear response in dmPFC between the different subtypes of INs.

Key words:

social fear, dorsal medial prefrontal cortex, inhibitory interneurons

Reference:

Menon, R., et al. Curr. Biol. 28, 1066–1078.e6. (2018)