Synaptic mechanisms of associative memory in the amygdala (Neuron, 2005, 47:783-786)

報告日期: 2006/05/26
報告時間: 16:00/16:50
報告學生: 徐袁章
講評老師: 簡伯武


Synaptic Mechanisms of Associative Memory in the Amygdala

Neuron 47, 783-786, 2005



Time: 2006/05/26  16:10~17:00                  Place: Room 602

Speaker: 基醫所博一 徐袁章                   Commentator: 簡伯武 老師



Animals continually adapt their behavior in response to changes in the environment. It has long been held that selective modifications in synaptic efficacy represent the physical substrate for this behavioral plasticity (1). Long-term potentiation (LTP), a cellular model of synaptic plasticity, has emerged as a leading candidate mechanism underlying associative forms of learning in the central nervous system (2). Pavlovian fear conditioning is an associative memory system that rapidly encodes memories of aversive events in both man and animals. In the laboratory, fear conditioning is established by presenting a neutral stimulus (the conditional stimulus, or CS), such as a tone, together with a noxious stimulus (the unconditional stimulus, or US), such as an electric shock to the feet. After a single conditioning trial, the CS will elicit a learned fear response (the conditional response, or CR), and this fear memory will persist for months, years, even a lifetime. Importantly, the population of synapses that is essential for encoding and storing fear memories has been identified. Recent work in the amygdala reveals that LTP and Pavlovian fear conditioning induce similar changes in postsynaptic AMPA-type glutamate receptors and that occluding these changes by viral-mediated overexpression of a dominant-negative GluR1 construct attenuates both LTP and fear memory in rats (3). Novel forms of presynaptic plasticity in the lateral nucleus may also contribute to fear memory formation, bolstering the connection between synaptic plasticity mechanisms and associative learning and memory.



1. D. O. Hebb, Organization of Behavior (Wiley, New York, 1949).

2. M. S. Rioult-Pedotti, D. Friedman, J. P. Donoghue. Science 290, 533, 2000.

3. Rumpel, S., LeDoux, J., Zador, A., and Malinow, R. Science 308, 83–88, 2005.