p38a MAP kinase as a sensor of reactive oxygen species in tumorigenesis (Cancer Cell, 2007, 11:191-205)

報告日期: 2007/11/02
報告時間: 17:10/18:00
報告學生: 楊淨雯
講評老師: 莊季瑛
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p38α MAP kinase as sensor of reactive oxygen species in tumorigenesis

Cancer cell, 11, 191-205, 2007

 

Speaker: 楊淨雯

Commentator: 莊季瑛

Time: 2007/11/02

Place: 602 Room

 

Abstract:

p38α MAPK plays an important role in the coordination of the cellular response to many stress stimuli. It has been shown that p38α can negatively regulate the malignant transformation induced by oncogenic H-Ras and several mechanisms have been proposed to explain this putative tumor-suppressor role, although the mechanisms are incompletely understood.  In this paper, the authors show that p38α is not a general inhibitor of oncogenic signaling, but that it specifically modulates malignant transformation induced by oncogenes that produce ROS. This inhibitory effect is due to the ROS-induced activation of p38α early in the process of transformation, which induces apoptosis and prevents the accumulation of ROS and their tumorigenic effects. In some human cancer cells, they can bypass the inhibitory role of p38α on ROS accumulation, thus enhanced their tumorigenicity. This paper indicates that oxidative stress sensing by p38α MAPK is an important mechanism by which to negatively regulate the onset of cancer.

 

References:

1. Dorion, S., H. Lambert, et al. (2002). "Activation of the p38 signaling pathway by heat shock involves the dissociation of Glutathione S-Transferase Mu from Ask1." J. Biol. Chem 277(34).       

2. Kennedy, N. J., C. Cellurale, et al. (2007). "A radical role for p38 MAPK in tumor initiation " Cancer cell 11(2).