Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production (Science, 2007, 317:121-124)

報告日期: 2007/10/05
報告時間: 15:10/16:00
報告學生: 楊明臻 (英文報告)
講評老師: 王育民
附件下載:

Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production

Science 2007, 317:121-4

Speaker:楊明臻  

Commentator:王育民 老師

Time:15:10-16:00

Place: Room 602

 

Abstract

Hepatocellular carcinoma (HCC) has high incidence rate in the world, especially in men. Male are three to five times more susceptible to develop HCC than female, this phenomenon also observed in animal model. The mechanisms for this gender disparity are unknown. Administration of chemical carcinogen diethylnitrosamine (DEN) will develop HCC with gender disparity feature. DEN exposure made greater increase of IL-6 in male than in female. Treatment of DEN to IL-6-/- mice abolished gender differences of HCC formation. The increase of IL-6 production may due to liver macrophage (Kupffer cell) activation after uptaking apoptotic body and subsequent MyD88-dependent signaling. Furthermore, blocking estrogen function in female mice also increased IL-6 expression, which leaded to HCC. Taken together, the authors indicated that IL-6 is an important factor promoting HCC development, while estrogen acting as a negative regulator of IL-6 and further reduced HCC formation in female. These findings could help us to prevent HCC in the future.

 

 

References

1.      Sander LE. Is Interlukin-6 a Gender-Specific Risk Factor for Liver Cancer? Hepatology. 2007, 46:1304-5.

2.      Bosch FX et al. Primary Liver Cancer: world Incidence and Trends. Gastroenerology. 2004, 127:S5-16.

3.      Chiu CM et al. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level. PNAS. 2007, 104:2571-8.