alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis (Nat Med, 2007, 13:836-842)

報告日期: 2007/10/09
報告時間: 15:10/16:00
報告學生: 林煥晴
講評老師: 謝奇璋
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a1b1 integrin is crucial for accumulation of epidermal T cells

and the development of psoriasis

Curdin C., Onur B., Giulia T., Adrian T., Ute L., Antonin de F., Victor K., Humphrey G., & Frank O N.

Nature Medicine 13, 836-842 (2007)

Speaker: Huan-Ching Lin                         

Commentator: Dr. Chi-Chang Shieh

 

Abstract:

Psoriasis, showing keratinocyte hyperplasia and thick epidermis, is an autoimmune disease mediated by T cells and inflammatory cytokines. It commonly causes red scaly patches on the skin. In the psoriasis plaques, active T cells are accumulated in the epidermis that is necessary for the psoriasis development. However, it is unclear whether tissue-specific factors regulate the activation and expression of tissue-resident T cells. Because human skin is rich in matrix and the active T cells express integrins, authors wanted to study the association between psoriasis and these factors. Their results showed that the epidermal T cells in psoriasis expressed abundant a1b1 integrin (known as very late antigen 1, VLA-1). These a1b1 T cells were not found in dermis of psoriasis lesion or normal epidermis. a1b1-positive T cells expressed protein markers of effector memory phenotype and high levels of interferon-g. To study the function of a1b1 integrin in development of psoriasis, the authors used a clinically relevant xenotransplantant model. Blocking a1b1 integrin with neutralized antibody decreased the number of epidermal T cells and development of psoriasis. In the psoriasis lesion, blockage of a1b1 also decreased cytokines expression. In summary, a1b1 integrin plays an important role of epidermal T cells accumulation and psoriasis development. In the future, blockage of a1b1 may be a promising treatment in preventing psoriasis development.

 

References: 1,2

1.   Bowcock, A.M. & Krueger, J.G. Getting under the skin: the immunogenetics of psoriasis. Nature reviews 5, 699-711 (2005).

2.   Boyman, O., Conrad, C., Tonel, G., Gilliet, M. & Nestle, F.O. The pathogenic role of tissue-resident immune cells in psoriasis. Trends in immunology 28, 51-57 (2007).