The angiogenic response is dictated by 3 integrin on bone marrow-derived cells (J Cell Biol, 2008, 183:1145-1157)

報告日期: 2009/03/31
報告時間: 17:10/18:00
報告學生: 黃俊豪
講評老師: 吳梨華

The angiogenic response is dictated by b3 integrin on bone marrowderived cells

J. Cell Biol. Vol. 183 No. 6 11451157(2008)


Weiyi Feng , N. Patrick McCabe , Ganapati H. Mahabeleshwar ,

Payaningal R. Somanath , David R. Phillips , and Tatiana V. Byzova


Speaker : 黃俊豪


Date : 2009.3.31

Room : 602教室



Angiogenesis is the induction and growth of new blood vessels. It is an important process in fetal development, wound healing, tissue repair and tumor growth. Bone marrow - derived cells (BMDCs) promote angiogenesis through the release of pro-angiogenic factors at site of neovascularization. In this study, they provided the mechanism of BMDC release, recruitment and retention at sites of neovascularization. They used the knockin mice (DiYF mice) expressing mutated b3 integrin to show that transplantation of wild-type bone marrow (BM) restored impaired tumor angiogenesis in these mice by normalizing recruitment, and the recruitment of BMDCs to site of neovascularization site was impaired after transplantation of DiYF BM. Further, they showed that reduced stromal derived factor-1 (SDF-1), a key factor for CXCR4+ BMDC retention in angiogenic tissues, led to impaired recruitment of CXCR4+ BMDC. Moreover, their data showed that function of b3 integrin was essential for adhesion and endothelial transmigration of CXCR4+ BMDCs. In conclusion, b3 integrin activity on circulation CXCR4+ BMDCs plays a key role in angiogenesis through regulation BMDC recruitment to angiogenic sites and adherence to and transmigration through endothelium.


Reference :

1.     Michele De Palma, Mary Anna Venneri, et al. CANCER CELL : SEPTEMBER VOL. 8 : 211-226 (2005)