Identification of cells initiating human melanomas (Nature, 2008, 451:345-349)

報告日期: 2008/11/04
報告時間: 15:10/16:00
報告學生: 謝宜珊
講評老師: 吳昭良
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/971114-1.pdf

Identification of cells initiating human melanomas

 

Nature 451, 345-349 (17 January 2008)

 

Speaker謝宜珊   

Commentator吳昭良 教授

Date2008/11/04

Time15:10-16:00

PlaceRoom 602

 

Abstract

Tumor-initiating cells , also termed cancer stem cells, have been identified in a variety of cancers. These cells have the capacity to sustain tumor growth and are defined by three features: self-renewal, differentiation into the cell types of the original cancer and potent tumor formation. ABCB5(ATP-binding cassette subfamily B member 5) is a novel drug transporter and chemoresistance mediator in human malignant melanoma. In this study, the authors found that a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the ABCB5. In serial human-to mouse xenotransplantation experiments, ABCB5 melanoma cells possess greater tumorigenic capacity than ABCB5bulk populations. Systemic administration of an anti-ABCB5 monoclonal antibody induces antibody-dependent cellular cytotoxicity in ABCB5-positive cells and inhibits tumor growth. Taken together, these results suggest that ABCB5 expression most likely contributes to chemoresistance of melanoma, it will be interesting to determine whether MMIC-targeted therapeutics can break this resistance.

 

Reference

1.   Frank, N. Y. et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 65, 43204333(2005).

2.    Frank, N. Y. et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J. Biol. Chem. 278, 47156-47165(2003).