Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease (PNAS, 2009, 106:13594-13599)

報告日期: 2009/12/04
報告時間: 17:10/18:00
報告學生: 賀豫君
講評老師: 郭余民
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/981204-3.pdf

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

 

PNAS (2009) 106:13594-13599

 

Speaker: Yu-Chun Ho (賀豫君)

Commentator: Dr.Yu-Min Kuo (郭余民老師)

Date: 2009/12/4 17:10-18:00

Place: Room 602

 

Abstract:

    Transplantation of stem cells or their derivatives has been proposed as a potential therapeutic strategy for neurological disorders associated with cognitive decline such as Alzheimer disease (AD). However, this approach has not been directly tested in transgenic AD models. In the present study, the authors used aged triple transgenic mice (3xTg-AD) to investigate the effects of neural stem cell (NSC) transplantation on AD-related neuropathology and cognitive dysfunction. Intriguingly, NSC transplantation rescues the spatial learning and memory deficits without altering established Ab plaque and neurofibrillary tangle pathology in aged 3xTg-AD mice. Instead, gain-of-function and loss-of-function studies demonstrate that NSC-derived cells increase synaptic density and restore hippocampus-dependent cognition via elevating hippocampal BDNF. Taken together, the results show that NSCs ameliorate cognitive deficits in 3xTg-AD mice by BDNF but not through diminishing widespread Alzheimer disease pathology. Based on this research, in the future we may benefit from the development of methods that chronically modulate neurotrophin levels in AD treatment.

 

References:

1.     Lindvall, O. and Kokaia, Z. (2006) Nature 441:1094-1096.

2.     Oddo, S. et al. (2003) Neuron 39:409-421.