Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation (Nat Neurosci, 2008, 11:457-166)

報告日期: 2008/12/12
報告時間: 15:10/16:00
報告學生: 賀豫君
講評老師: 簡伯武
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/971212-1.pdf

Motor protein-dependent transport of AMPA receptors into

spines during long-term potentiation

Nat. Neurosci. (2008) 11:457-466

 

Speaker: Yu-Chun Ho (賀豫君)

Commentator: Dr. Po-Wu Gean (簡伯武老師)

Date: 2008/12/12 15:10-16:00

Place: Room 602

 

Abstract:

    AMPA-type glutamate receptors (AMPARs) are responsible for most excitatory synaptic transmission in the brain, and their regulated trafficking at synapses is crucial for synaptic plasticity, such as long-term potentiation (LTP). However, the detailed molecular mechanism underlying this activity-dependent AMPAR transport remains uncertain. The authors discovered that myosin Va, an actin-based motor protein present in the postsynaptic site, associates with GluR1 (a subunit of the AMPAR) carboxyl terminus through its cargo binding domain. In addition, myosin Va is essential for several forms of regulated synaptic delivery of GluR1-containing AMPARs: LTP induction, CaMKII activation, and PSD-95 overexpression. In contrast, myosin Va is not required for the constitutive entry of AMPARs into postsynaptic sites. Notably, myosin Va specifically mediates the short-range translocation of GluR1-containing AMPARs from the dendritic shaft into the spine head rather than the long-range trafficking of receptors along dendrites. Finally, the authors identified the small GTPase Rab11 as a vesicular carrier that facilitates the interaction between GluR1 and myosin Va during their transport into spines. Taken together, the results demonstrate that myosin Va and its organelle acceptor Rab11 are critically involved in the directional transport of AMPARs during synaptic plasticity.

 

References:

1.     Shepherd, J.D. and Huganir, R.L. (2007) Annu. Rev. Cell Dev. Biol. 23:613-643.

2.     Naisbitt, S. et al. (2000) J. Neurosci. 20:4524-4534.