A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow (Plos One, 2008, 3(6); e2338:1-10)

報告日期: 2008/12/16
報告時間: 17:05/17:55
報告學生: 王雅惠
講評老師: 謝奇璋
附件下載:

http://basicmed.med.ncku.edu.tw/admin/up_img/971216-3.pdf

A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow

 

Speaker:王雅惠

Commentator:謝奇璋 教授

Date2008/12/16

Place602教室

 

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is a molecule expressed very high levels on the surface of endothelial cells and at moderate levels on most hematopoietic cells. PECAM-1 acts as an important factor in regulating cell adhesion, migration and activation in haematopoietic cells, and contributes to several important processes in vasculature. In previous studies, the authors found PECAM-1 can control megakaryocyte migration by polarization of CXCR4 and regulation the adhesion to bone marrow matrix proteins. The haematopoitic stem cells (HSCs) mobilization or homing between born marrow and circulation has been shown to be regulated by CXCL12 (SDF-1) and its receptor CXCR4 interaction. In this paper, they wanted to investigate the physiological role of PECAM-1 in the bi-directional movement of HSCs between the vascular niche and circulation. The experiment results demonstrated PECAM-1−/− mice exhibited an increase in the number of circulating progenitor cells in the resting state due to defect of HSCs migration to CXCL12 and increased levels of MMP-9 in bone marrow. These findings further support a novel role for PECAM-1 in modulating cellular migration and adhesion and as a regulator of HSCs mobilization.

 

Reference:

1.   Dhanjal, TS; Pendaries, C; Ross, EA; Larson, MK; Protty, MB, et al. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood. 2007;109:4237–4244.   

2.   Petit, I; Szyper-Kravitz, M; Nagler, A; Lahav, M; Peled, A, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3:687–694